Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell–mediated cytotoxicity
Tuli A, Thiery J, James A, Michelet X, Sharma M, Garg S, Sanborn K, Orange J, Lieberman J, Brenner M. Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell–mediated cytotoxicity. Molecular Biology Of The Cell 2013, 24: 3721-3735. PMID: 24088571, PMCID: PMC3842998, DOI: 10.1091/mbc.e13-05-0259.Peer-Reviewed Original ResearchConceptsLysosome-related organellesMicrotubule-organizing centerImmune synapseKinesin-1Lytic granulesPolarization of lytic granulesGTP-binding proteinsPull-down approachMovement of lysosomesGranule polarizationLytic granule polarizationKinesin family member 5BNatural killer cell-mediated cytotoxicityNK cell lysatesFormation of immune synapseADP-ribosylationTripartite complexArl8bTarget cell membraneInteraction partnersAnterograde movementCell lysatesTarget cellsMember 5BCell membrane
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