2012
Human genetic variation of CYP450 superfamily: analysis of functional diversity in worldwide populations
Polimanti R, Piacentini S, Manfellotto D, Fuciarelli M. Human genetic variation of CYP450 superfamily: analysis of functional diversity in worldwide populations. Pharmacogenomics 2012, 13: 1951-1960. PMID: 23215887, DOI: 10.2217/pgs.12.163.Peer-Reviewed Original ResearchConceptsGenetic diversityHuman genetic diversityHuman genetic variationHuman Genome Diversity ProjectFunctional differencesHuman populationRole of CYP450Functional diversityGenetic variationRelated clinical phenotypesHigh differentiationCYP450 genesHapMap dataDiversity ProjectHuman adaptationF-statisticsDiversityGenesWorldwide populationDrug responseComputational analysisClinical phenotypeAdaptationCYP450Interethnic differences
1999
Frequency of functionally important beta-2 adrenoceptor polymorphisms varies markedly among African-American, Caucasian and Chinese individuals.
Xie HG, Stein CM, Kim RB, Xiao ZS, He N, Zhou HH, Gainer JV, Brown NJ, Haines JL, Wood AJ. Frequency of functionally important beta-2 adrenoceptor polymorphisms varies markedly among African-American, Caucasian and Chinese individuals. Pharmacogenetics And Genomics 1999, 9: 511-6. PMID: 10780271.Peer-Reviewed Original ResearchConceptsAfrican American individualsChinese individualsEthnic differencesSeverity of hypertensionDifferent ethnic groupsBeta-2 adrenergic receptorsMarked ethnic differencesEthnic groupsAdrenoceptor polymorphismsBAR agonistsGlu27 polymorphismGly16 alleleGlu27 alleleVascular responsesDisease manifestationsHealthy individualsAdrenergic receptorsCommon polymorphismsMarked interethnic differencesInterethnic differencesHomozygous genotypeGln27Arg16PolymorphismAlterations
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