2022
PET imaging of mitochondrial function in acute doxorubicin-induced cardiotoxicity: a proof-of-principle study
Detmer F, Alpert N, Moon S, Dhaynaut M, Guerrero J, Guehl N, Xing F, Brugarolas P, Shoup T, Normandin M, Pelletier-Galarneau M, El Fakhri G, Petibon Y. PET imaging of mitochondrial function in acute doxorubicin-induced cardiotoxicity: a proof-of-principle study. Scientific Reports 2022, 12: 6122. PMID: 35414642, PMCID: PMC9005533, DOI: 10.1038/s41598-022-10004-6.Peer-Reviewed Original ResearchConceptsLeft anterior descending coronary arteryDoxorubicin-induced cardiotoxicityCardiac membrane potentialDoxorubicin infusionMembrane potentialAnimal modelsAcute doxorubicin-induced cardiotoxicityLeft anterior descending coronary artery territoryAcute cardiotoxic effectsAnterior descending coronary arteryControl saline infusionDescending coronary arteryDoxorubicin doseSaline infusionTest infusionCardiotoxic effectsMitochondrial membrane potentialInfusion catheterCoronary arteryInfusionMitochondrial functionDoxorubicinMyocardial areaPET imagingIntracoronary catheter
2009
Hypercoagulability in a patient with chronic chyluria, proteinuria and hypoalbuminaemia
Golestaneh L, Karam S, Lawrence J, Yang S, Greenberg M. Hypercoagulability in a patient with chronic chyluria, proteinuria and hypoalbuminaemia. Nephrology Dialysis Transplantation 2009, 24: 3240-3243. PMID: 19531672, DOI: 10.1093/ndt/gfp283.Peer-Reviewed Original ResearchConceptsIncreased clotting tendencyClotting tendencyFactor VIII levelsLeft anterior descending coronary arteryAnterior descending coronary arteryRisk of hypercoagulabilityDescending coronary arteryAcute myocardial infarctionHypo-albuminemiaSecondary polycythemiaCoronary arteryMyocardial infarctionSevere chyluriaChronic dehydration
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