2024
Generation of transmitochondrial cybrids in cancer cells
Soler-Agesta R, Ripollés-Yuba C, Marco-Brualla J, Moreno-Loshuertos R, Sato A, Beltrán-Visiedo M, Galluzzi L, Anel A. Generation of transmitochondrial cybrids in cancer cells. Methods In Cell Biology 2024, 189: 23-40. PMID: 39393884, DOI: 10.1016/bs.mcb.2024.05.010.Peer-Reviewed Original ResearchTransmitochondrial cybridsCancer cellsApoptotic cell deathSource of ATPCancer cell functionsMitochondrial genomeCircular genomeNuclear genesMitochondrial DNATransfer RNAMitochondrial proteinsRibosomal RNAMitochondrial componentsIntact mitochondriaMitochondrial functionCybridsCell deathMetabolic intermediatesMitochondriaGenomeCell functionRNACellsTumor progressionAbundant source
1985
Arginine in the leader peptide is required for both import and proteolytic cleavage of a mitochondrial precursor.
Horwich A, Kalousek F, Rosenberg L. Arginine in the leader peptide is required for both import and proteolytic cleavage of a mitochondrial precursor. Proceedings Of The National Academy Of Sciences Of The United States Of America 1985, 82: 4930-4933. PMID: 3895227, PMCID: PMC390471, DOI: 10.1073/pnas.82.15.4930.Peer-Reviewed Original ResearchConceptsLeader peptideOrnithine transcarbamoylaseImport of precursorsMost mitochondrial proteinsMitochondrial matrix fractionOverall amino acid compositionMitochondrial matrix enzymeMitochondrial precursorsMitochondrial proteinsSubunit precursorAmino acid compositionBasic arginine residuesBasic residuesMatrix enzymeGlycine residueLarger precursorArginine residuesMatrix fractionIntact mitochondriaNH2-terminalDependent proteaseProteolytic cleavageTranscarbamoylaseResiduesMitochondria
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