Mucosal immune alterations at the early onset of tissue destruction in chronic obstructive pulmonary disease
de Fays C, Geudens V, Gyselinck I, Kerckhof P, Vermaut A, Goos T, Vermant M, Beeckmans H, Kaes J, Van Slambrouck J, Mohamady Y, Willems L, Aversa L, Cortesi E, Hooft C, Aerts G, Aelbrecht C, Everaerts S, McDonough J, De Sadeleer L, Gohy S, Ambroise J, Janssens W, Ceulemans L, Van Raemdonck D, Vos R, Hackett T, Hogg J, Kaminski N, Gayan-Ramirez G, Pilette C, Vanaudenaerde B. Mucosal immune alterations at the early onset of tissue destruction in chronic obstructive pulmonary disease. Frontiers In Immunology 2023, 14: 1275845. PMID: 37915582, PMCID: PMC10616299, DOI: 10.3389/fimmu.2023.1275845.Peer-Reviewed Original ResearchConceptsCD8+ T cell accumulationT cell accumulationImmune alterationsTerminal bronchiolesTissue destructionCOPD lungsCD4+ T cellsMyeloid antigen-presenting cellsAntigen-presenting cellsSmall airway changesTissue destructive processesChronic airway inflammationInnate immune alterationsB cell activationMucosal immune defenseAdaptive immune responsesChronic obstructive pulmonary diseaseObstructive pulmonary diseaseIncreased mucus productionAlveolar surface densityAirway changesT cellsAirway inflammationImmune cellsB cells
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