Targeting therapeutic vulnerabilities with PARP inhibition and radiation in IDH-mutant gliomas and cholangiocarcinomas
Wang Y, Wild A, Turcan S, Wu W, Sigel C, Klimstra D, Ma X, Gong Y, Holland E, Huse J, Chan T. Targeting therapeutic vulnerabilities with PARP inhibition and radiation in IDH-mutant gliomas and cholangiocarcinomas. Science Advances 2020, 6: eaaz3221. PMID: 32494639, PMCID: PMC7176409, DOI: 10.1126/sciadv.aaz3221.Peer-Reviewed Original ResearchIDH-mutant gliomasIsocitrate dehydrogenaseAnimal models of gliomaReduced DNA damage repairRibose polymerase inhibitorsLocal radiation therapyTarget solid tumorsPreclinical animal modelsIsocitrate dehydrogenase mutationModel of gliomaMutant isocitrate dehydrogenaseSynthetic lethal approachTargetable therapeutic vulnerabilitiesDNA damage repairMultiple cancer typesRadiation therapyMultimodal therapyMultiple in vitroSolid tumorsElevated DNA damageTherapeutic vulnerabilitiesTumor cellsPARP inhibitionTreatment strategiesPolymerase inhibitors
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