2023
Clinical relevance of PD-1 positive CD8 T-cells in gastric cancer
Choo J, Kua L, Soe M, Asuncion B, Tan B, Teo C, Tay R, So J, Shabbir A, Guowei K, Tan H, Chan G, Ma H, Ramachandran G, Lum J, Chee C, Sridharan S, Tan P, Sundar R, Yong W. Clinical relevance of PD-1 positive CD8 T-cells in gastric cancer. Gastric Cancer 2023, 26: 393-404. PMID: 36781556, PMCID: PMC10115710, DOI: 10.1007/s10120-023-01364-7.Peer-Reviewed Original ResearchConceptsCD8 T cellsPD-1+CD8+ T cellsT cellsTumor microenvironmentPD-1Overall survivalGastric cancerMultiplex immunohistochemistryT cell-inflamed tumor microenvironmentAssociated with improved OSIncreased PD-1 expressionClinical relevanceGranzyme-B expressionInflamed tumor microenvironmentPD-1 expressionInfluence overall survivalNK cell proportionTreated with immunotherapyPhase 2 trialAssociated with chemotherapyCox proportional hazards modelsProportional hazards modelImproved OSImmunotherapy sensitivityNK cells
2022
Effect of concurrent beta-blocker use in patients receiving immune checkpoint inhibitors for advanced solid tumors
Mellgard G, Patel V, Zhong X, Joshi H, Qin Q, Wang B, Parikh A, Jun T, Alerasool P, Garcia P, Gogerly-Moragoda M, Leiter A, Gallagher E, Oh W, Galsky M, Tsao C. Effect of concurrent beta-blocker use in patients receiving immune checkpoint inhibitors for advanced solid tumors. Journal Of Cancer Research And Clinical Oncology 2022, 149: 2833-2841. PMID: 35788726, PMCID: PMC10739778, DOI: 10.1007/s00432-022-04159-y.Peer-Reviewed Original ResearchConceptsImmune checkpoint blockadeClinical activity of immune checkpoint blockadeAdvanced solid tumorsOverall survivalT cell activationClinical outcomesSolid tumorsCD8+ T cell activationClinical activityClinical outcomes of patientsAdrenergic signalingAntitumor immune activityPharmacological beta-blockadeUrothelial carcinoma cohortImmune checkpoint inhibitorsInfluence overall survivalCox proportional hazards regression modelsDuration of therapyAssociation of OSOutcomes of patientsBeta-blocker useDisease control statusProportional hazards regression modelsBeta-adrenergic signalingInhibited tumor growth
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