2021
Testing the effects of the GLP-1 receptor agonist exenatide on cocaine self-administration and subjective responses in humans with cocaine use disorder
Angarita GA, Matuskey D, Pittman B, Costeines JL, Potenza MN, Jastreboff AM, Schmidt HD, Malison RT. Testing the effects of the GLP-1 receptor agonist exenatide on cocaine self-administration and subjective responses in humans with cocaine use disorder. Drug And Alcohol Dependence 2021, 221: 108614. PMID: 33621809, PMCID: PMC8026565, DOI: 10.1016/j.drugalcdep.2021.108614.Peer-Reviewed Original ResearchConceptsCocaine use disorderGLP-1Use disordersGLP-1 receptor agonist exenatideGlucagon-like peptide-1 analogSubjective effectsEfficacy of exenatideLevels of amylinPreclinical rodent studiesPeptide-1 analogVisual analog scaleGLP-1 analoguesSelf-reported euphoriaInfusion of cocaineSelf-administer cocaineAcute pretreatmentSecondary outcomesPrimary outcomeAnalog scaleHormone levelsRodent studiesExenatidePlaceboCocaine infusionsCUD subjects
2016
The Naturally Occurring Compound Garcinia Indica Selectively Impairs the Reconsolidation of a Cocaine-Associated Memory
Monsey MS, Sanchez H, Taylor JR. The Naturally Occurring Compound Garcinia Indica Selectively Impairs the Reconsolidation of a Cocaine-Associated Memory. Neuropsychopharmacology 2016, 42: 587-597. PMID: 27380937, PMCID: PMC5240167, DOI: 10.1038/npp.2016.117.Peer-Reviewed Original ResearchConceptsCocaine-cue memoriesCocaine self-administration trainingLight/tone cuesCue-induced cocaine-seeking behaviorCocaine-associated memorySelf-administration trainingCocaine-seeking behaviorActive lever pressesCue memoryInfusion of cocaineLever extinctionReconsolidation processTone cuesSuch cuesDrug takingMemoryLever pressesCuesReconsolidationNew responsesAbstinenceDrug abuseEnvironmental stimuliCocaine useCocaine access
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