A Pharmacokinetic/Pharmacodynamic Model for Recombinant Human Growth Hormone Effects on Induction of Insulin-Like Growth Factor I in Monkeys 1
Sun Y, Lee H, Almon R, Jusko W. A Pharmacokinetic/Pharmacodynamic Model for Recombinant Human Growth Hormone Effects on Induction of Insulin-Like Growth Factor I in Monkeys 1. Journal Of Pharmacology And Experimental Therapeutics 1999, 289: 1523-1532. PMID: 10336548, DOI: 10.1016/s0022-3565(24)38301-6.Peer-Reviewed Original ResearchConceptsRecombinant human growth hormoneIGF-I inductionInduction of insulin-like growth factor-IInsulin-like growth factor-IGrowth factor-IIGF-IGroup BGroup ARhGH treatment groupOsmotic pumpRhGH effectHuman growth hormones’ effectsSustained-release microsphere formulationPharmacokinetic/Pharmacodynamic ModelFactor IGroup CIGF-I productionImplanted osmotic pumpDaily subcutaneous injectionsZero-order inputOsmotic pump deliveryHuman growth hormoneIndirect response modelShort-term i.Two-compartment model
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply