2017
GRAPE: a pathway template method to characterize tissue-specific functionality from gene expression profiles
Klein MI, Stern DF, Zhao H. GRAPE: a pathway template method to characterize tissue-specific functionality from gene expression profiles. BMC Bioinformatics 2017, 18: 317. PMID: 28651562, PMCID: PMC5485588, DOI: 10.1186/s12859-017-1711-z.Peer-Reviewed Original ResearchConceptsGene expression profilesExpression profilesIndividual gene expression profilesTissue-specific functionalityEnrichment-based methodsPathway scoresGene expression levelsBatch effectsPathway genesPresent genesPerturbed pathwaysPathway expressionExpression levelsIndividual samplesTissue typesPathwayGenesTCGA subtypesAbnormal pathwaysIndependent datasetsBreast cancer subtypesNon-competitive approachIndividual tumorsCancer subtypesGrapes
2015
Impact of recent innovations in the use of mass cytometry in support of drug development
Nassar AF, Ogura H, Wisnewski AV. Impact of recent innovations in the use of mass cytometry in support of drug development. Drug Discovery Today 2015, 20: 1169-1175. PMID: 26092491, PMCID: PMC4668584, DOI: 10.1016/j.drudis.2015.06.001.Peer-Reviewed Original ResearchConceptsSingle-cell technologiesSingle-cell levelDrug developmentSingle cellsDiseased statesCell levelMechanism of actionMass cytometryCellsDrug profilingIndividual biological cellsCyTOFImportant roleSignal overlapCytometryIndividual samplesBiological cellsProfilingSignificant advancesCell technology
2014
Genome‐wide association discoveries of alcohol dependence
Zuo L, Lu L, Tan Y, Pan X, Cai Y, Wang X, Hong J, Zhong C, Wang F, Zhang X, Vanderlinden LA, Tabakoff B, Luo X. Genome‐wide association discoveries of alcohol dependence. American Journal On Addictions 2014, 23: 526-539. PMID: 25278008, PMCID: PMC4187224, DOI: 10.1111/j.1521-0391.2014.12147.x.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesGenome-wide levelPotential biological functionsGWAS samplesADH clusterGenome-wide association discoveryRisk variantsBiological functionsAlcohol dehydrogenase clusterWide significant associationsRobust risk locusCis-eQTLsRisk lociNrd1Association studiesKIAA0040PKNOX2RNA expressionImportant roleHTR7Replicable associationsIndividual samplesSERINC2Mouse brainVariants
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