2024
Parameter optimization for stable clustering using FlowSOM: a case study from CyTOF
Tao W, Sinha A, Raddassi K, Pandit A. Parameter optimization for stable clustering using FlowSOM: a case study from CyTOF. Frontiers In Immunology 2024, 15: 1414400. PMID: 39445014, PMCID: PMC11497637, DOI: 10.3389/fimmu.2024.1414400.Peer-Reviewed Original ResearchParameter optimizationMachine learning methodologyMachine learningComplex dataClustering outcomesLearning methodologyAssociated with immune disordersModified pipelineCell phenotypeImmune cell populationsDatasetBugsAutomated gatingOptimizationMachineImmunological datasetsImmune disordersScalabilityStable clustersCell populationsPipelineCellular changesCase studyCyTOFCyTOF data
2015
Impact of recent innovations in the use of mass cytometry in support of drug development
Nassar AF, Ogura H, Wisnewski AV. Impact of recent innovations in the use of mass cytometry in support of drug development. Drug Discovery Today 2015, 20: 1169-1175. PMID: 26092491, PMCID: PMC4668584, DOI: 10.1016/j.drudis.2015.06.001.Peer-Reviewed Original ResearchConceptsSingle-cell technologiesSingle-cell levelDrug developmentSingle cellsDiseased statesCell levelMechanism of actionMass cytometryCellsDrug profilingIndividual biological cellsCyTOFImportant roleSignal overlapCytometryIndividual samplesBiological cellsProfilingSignificant advancesCell technology
2014
CyTOF supports efficient detection of immune cell subsets from small samples
Yao Y, Liu R, Shin MS, Trentalange M, Allore H, Nassar A, Kang I, Pober JS, Montgomery RR. CyTOF supports efficient detection of immune cell subsets from small samples. Journal Of Immunological Methods 2014, 415: 1-5. PMID: 25450003, PMCID: PMC4269324, DOI: 10.1016/j.jim.2014.10.010.Peer-Reviewed Original ResearchConceptsImmune cell subsetsCell subsetsImmune cell statesPatient biopsiesTranslational investigationsFlow cytometryClinical researchCellular analysisMass cytometryMultiple cell populationsCell populationsCytometryCyTOFSingle-cell analysisMultiparameter single cell analysisFluorescence cytometryFluorescence-based flow cytometryCell statesHuman diseasesMarkersTremendous detailBiopsyPathogenesis
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply