Oncogenic Mechanisms and Therapeutic Targeting of Metabolism in Leukemia and Lymphoma
Stahl M, Epstein-Peterson Z, Intlekofer A. Oncogenic Mechanisms and Therapeutic Targeting of Metabolism in Leukemia and Lymphoma. Cold Spring Harbor Perspectives In Medicine 2020, 11: a035477. PMID: 32816875, PMCID: PMC8247556, DOI: 10.1101/cshperspect.a035477.Peer-Reviewed Original ResearchConceptsIncreased acquisition of nutrientsRegulate cell fateAcquisition of nutrientsMetabolically active cancer cellsBuffer oxidative stressActive cancer cellsUnrestrained cell growthAccelerated metabolic processesRapid cell divisionBiosynthetic reactionsPromote terminal differentiationCell fateCell biomassCell divisionReducing equivalentsCell growthMalignant cellsLymphoma cellsMetabolic processesTherapeutic vulnerabilitiesBiomass accumulationTerminal differentiationIntermediary metabolismLymphomaRedox balance
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