Tumor cell lines established in vitro: an independent prognostic factor for survival in non-small-cell lung cancer.
Stevenson H, Gazdar A, Phelps R, Linnoila R, Ihde D, Ghosh B, Walsh T, Woods E, Oie H, O'Connor T, Makuch R, Kramer B, Mulshine J. Tumor cell lines established in vitro: an independent prognostic factor for survival in non-small-cell lung cancer. Annals Of Internal Medicine 1990, 113: 764-70. PMID: 1700655, DOI: 10.7326/0003-4819-113-10-764.Peer-Reviewed Original ResearchConceptsNon-small-cell lung cancerTumor cell linesMedian survivalLung cancerRadiation therapyTumor specimensCell linesTumor tissuesMultivariate analysisTreated with radiation therapyTreated with surgical resectionIn vitro drug sensitivityUnivariate analysis of survivalCorrelated to clinical outcomeDecreased patient survivalLog-rank testIn vitro tumor growthIndicator of prognosisAnalysis of survivalStep-down techniqueSurgical resectionConsecutive patientsPrognostic factorsPalliative therapyBiological aggressiveness
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