2024
Impact of Sepsis and Stress Hematopoiesis on the Acquisition and Persistence of Clonal Hematopoiesis
Ogbue O, Kewan T, Unlu S, Lakhotiya K, Mehkri O, Ellison R, Fadell F, Reynolds M, Cheema A, Durmaz A, Brady Z, VanOudenhove J, Singh A, Visconte V, Mendez L, Bosler D, Duggal A, Halene S, Al-Jaghbeer M, Maciejewski J, Gurnari C. Impact of Sepsis and Stress Hematopoiesis on the Acquisition and Persistence of Clonal Hematopoiesis. Blood 2024, 144: 5634-5634. DOI: 10.1182/blood-2024-209240.Peer-Reviewed Original ResearchChipSequential Organ Failure AssessmentClonal hematopoiesisStress hematopoiesisEmergence of CHMedian followOrgan dysfunctionMyeloid genesClonal hematopoiesis of indeterminate potentialDegree of organ dysfunctionFrequent somatic variantsOvert septic shockHistory of malignancyAssociated with higher incidenceLongitudinal blood samplesOrgan Failure AssessmentHistory of smokingObservational multicenter studyDiagnosis of sepsisImpact of sepsisDegree of leukocytosisMultivariate logistic regressionRecurrent infectious episodesClonal burdenMedian ANC
2016
Outcomes of Older Adults With Sepsis at Admission to an Intensive Care Unit
Rowe T, Araujo KL, Van Ness PH, Pisani MA, Juthani-Mehta M. Outcomes of Older Adults With Sepsis at Admission to an Intensive Care Unit. Open Forum Infectious Diseases 2016, 3: ofw010. PMID: 26925430, PMCID: PMC4766385, DOI: 10.1093/ofid/ofw010.Peer-Reviewed Original ResearchAssociation of sepsisICU admissionOlder adultsBaseline characteristicsSystemic inflammatory response syndrome criteriaIntensive care unit admissionCox proportional hazards modelImpact of sepsisCare unit admissionProspective cohort studyDiagnosis of sepsisDefinition of sepsisIntensive care unitMain outcome measuresProportional hazards modelUnit admissionSyndrome criteriaCohort studyCare unitOutcome measuresSepsisHazards modelAdmissionMortalityEarly use
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