2021
Progranulin associates with Rab2 and is involved in autophagosome-lysosome fusion in Gaucher disease
Zhao X, Liberti R, Jian J, Fu W, Hettinghouse A, Sun Y, Liu C. Progranulin associates with Rab2 and is involved in autophagosome-lysosome fusion in Gaucher disease. Journal Of Molecular Medicine 2021, 99: 1639-1654. PMID: 34453183, PMCID: PMC8541919, DOI: 10.1007/s00109-021-02127-6.Peer-Reviewed Original ResearchConceptsLysosomal storage diseaseGaucher diseaseAutophagosome-lysosome fusionCommon lysosomal storage diseasePGRN deficiencyNovel therapiesAnimal modelsProgranulinLC3-IIMolecular targetsCrucial mediatorCritical moleculesStorage diseaseDiseaseAutophagic fluxC-terminal fragmentImpaired fusionPatient fibroblastsAutophagyImpairmentKey regulator
2014
PI(4,5)P2 regulates myoblast fusion through Arp2/3 regulator localization at the fusion site
Bothe I, Deng S, Baylies M. PI(4,5)P2 regulates myoblast fusion through Arp2/3 regulator localization at the fusion site. Development 2014, 141: 2289-2301. PMID: 24821989, PMCID: PMC4034421, DOI: 10.1242/dev.100743.Peer-Reviewed Original ResearchMeSH KeywordsActin-Related Protein 2-3 ComplexActinsAnimalsCell CommunicationCell MembraneCytoskeletonDrosophila melanogasterGene Expression Regulation, DevelopmentalGenotypeMuscle Fibers, SkeletalMutationMyoblastsPhosphatidylinositol 4,5-DiphosphatePhospholipidsrac GTP-Binding ProteinsSignal TransductionConceptsF-actinRegulation of F-actin dynamicsActivator of actin polymerizationFusion siteF-actin fociMyoblast fusionF-actin dynamicsRegulation of actinCell-cell fusionActin regulatorsActin fociActin remodelingActin polymerizationPhosphoinositide PI(4,5)P2Regulates localizationCytoskeleton signalingOpposing membranesPI(4,5)P2ActinImpaired fusionArp2/3Receptor engagementCytoskeletonRegulationEnrichment
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply