2024
Impact of trauma exposure and depression comorbidity on response to transdiagnostic behavioral therapy for pediatric anxiety and depression
Angulo F, Goger P, Brent D, Rozenman M, Gonzalez A, Schwartz K, Porta G, Lynch F, Dickerson J, Weersing V. Impact of trauma exposure and depression comorbidity on response to transdiagnostic behavioral therapy for pediatric anxiety and depression. Npj Mental Health Research 2024, 3: 8. PMID: 38609501, PMCID: PMC10955846, DOI: 10.1038/s44184-023-00049-4.Peer-Reviewed Original ResearchBrief behavioral therapyTrauma exposureBehavioral therapyComorbid depressionModerators of treatment outcomeEffectiveness of psychotherapeutic interventionsDevelopment of comorbid depressionHistory of trauma exposureImpact of trauma exposureTherapist-rated measureTransdiagnostic behavior therapyMeasures of allianceSignificant three-way interactionClinically significant depressionThree-way interactionPresence of clinically significant depressionTransdiagnostic psychotherapyPediatric anxietyTransdiagnostic therapiesAnxiety symptomsDepression comorbidityPsychotherapeutic interventionsEmotional disordersHomework completionModel of learning
2020
Exploring the impact of trauma type and extent of exposure on posttraumatic alterations in 5-HT1A expression
Lewis M, Jones R, Davis M. Exploring the impact of trauma type and extent of exposure on posttraumatic alterations in 5-HT1A expression. Translational Psychiatry 2020, 10: 237. PMID: 32678079, PMCID: PMC7366706, DOI: 10.1038/s41398-020-00915-1.Peer-Reviewed Original ResearchConceptsTrauma typesTrauma exposureImpact of trauma typeExposure to potentially traumatic eventsSerotonin 1 A receptorExpression of 5-HT1AImpact of trauma exposureTrauma-exposed individualsRegulating serotonin releasePotentially traumatic eventsG protein-coupled serotonin receptorsImpact of traumaNeurobiological impactNeurobiological effectsHTR1A genePsychiatric syndromesEmotional behaviorPsychiatric symptomsStress respondingSerotonin receptorsTraumatic eventsSerotonin releaseExtent of exposureHuman literatureTrauma-induced changes
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