2022
Identification of tumour immune infiltration-associated snoRNAs (TIIsno) for predicting prognosis and immune landscape in patients with colon cancer via a TIIsno score model
Cai C, Peng Y, Shen E, Wan R, Gao L, Gao Y, Zhou Y, Huang Q, Chen Y, Liu P, Guo C, Feng Z, Zhang X, Liu Y, Shen H, Zeng S, Han Y. Identification of tumour immune infiltration-associated snoRNAs (TIIsno) for predicting prognosis and immune landscape in patients with colon cancer via a TIIsno score model. EBioMedicine 2022, 76: 103866. PMID: 35144219, PMCID: PMC8844792, DOI: 10.1016/j.ebiom.2022.103866.Peer-Reviewed Original ResearchConceptsImmune cellsColon cancerImmune landscapeTumor microenvironmentImmune checkpoint expression levelsTumor-infiltrating immune cellsBiomarkers of immunotherapy responseCentral Universities of Central South UniversityNational Key R & D ProgramTumor-related deathColon cancer cell linesCell linesNatural Science Foundation of Hunan ProvinceImmune cell linesMSI-H patientsCentral South UniversityPrognosis of CC patientsImmunotherapy efficacyCancer cell linesImmunotherapy responseImmune scoreInfiltration levelsPredicting PrognosisScore modelCC patients
2020
Prioritizing disease and trait causal variants at the TNFAIP3 locus using functional and genomic features
Ray JP, de Boer CG, Fulco CP, Lareau CA, Kanai M, Ulirsch JC, Tewhey R, Ludwig LS, Reilly SK, Bergman DT, Engreitz JM, Issner R, Finucane HK, Lander ES, Regev A, Hacohen N. Prioritizing disease and trait causal variants at the TNFAIP3 locus using functional and genomic features. Nature Communications 2020, 11: 1237. PMID: 32144282, PMCID: PMC7060350, DOI: 10.1038/s41467-020-15022-4.Peer-Reviewed Original ResearchConceptsChromatin accessible regionsGenome-wide association studiesDisease-associated lociGenetic variantsCausal genetic variantsDisease-Associated VariantsComplex traitsGenetic variationRegulatory regionsGenomic featuresCausal variantsRegulatory potentialAssociation studiesReporter activityDisease-associated haplotypeLinkage disequilibriumCommon variantsTight linkage disequilibriumExperimental assaysCell linesImmune cell linesLociAccessible regionsTNFAIP3TNFAIP3 locus
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