The cold immunological landscape of ATM-deficient cancers
Sinha S, Ng V, Novaj A, Zhu Y, Yazaki S, Pei X, Derakhshan F, Pareja F, Setton J, Naulin F, Beltrán-Visiedo M, Shin E, Longhini A, Gardner R, Ma J, Ma K, Roulston A, Morris S, Koehler M, Powell S, Rosen E, Galluzzi L, Reis-Filho J, Khan A, Riaz N. The cold immunological landscape of ATM-deficient cancers. Journal For ImmunoTherapy Of Cancer 2025, 13: e010548. PMID: 40350205, PMCID: PMC12067784, DOI: 10.1136/jitc-2024-010548.Peer-Reviewed Original ResearchConceptsImmune checkpoint blockadeCheckpoint blockadeTumor immunogenicityCell infiltrationLung cancerResponse to immune checkpoint blockadeNull tumorsATR inhibitionImmune effector cell infiltrationDesign of novel combination therapiesI interferonATM-deficient cancersEffector cell infiltrationEnhance tumor immunogenicityIncreasing tumor antigenicityNovel combination therapiesImmune cell infiltrationImmune cell recruitmentTriple-negative breastType I IFN signalingActivity of etoposideSynthetic lethal strategyActivation of type I interferonDefective DNA repairType I interferon
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