2025
The cold immunological landscape of ATM-deficient cancers
Sinha S, Ng V, Novaj A, Zhu Y, Yazaki S, Pei X, Derakhshan F, Pareja F, Setton J, Naulin F, Beltrán-Visiedo M, Shin E, Longhini A, Gardner R, Ma J, Ma K, Roulston A, Morris S, Koehler M, Powell S, Rosen E, Galluzzi L, Reis-Filho J, Khan A, Riaz N. The cold immunological landscape of ATM-deficient cancers. Journal For ImmunoTherapy Of Cancer 2025, 13: e010548. PMID: 40350205, PMCID: PMC12067784, DOI: 10.1136/jitc-2024-010548.Peer-Reviewed Original ResearchConceptsImmune checkpoint blockadeCheckpoint blockadeTumor immunogenicityCell infiltrationLung cancerResponse to immune checkpoint blockadeNull tumorsATR inhibitionImmune effector cell infiltrationDesign of novel combination therapiesI interferonATM-deficient cancersEffector cell infiltrationEnhance tumor immunogenicityIncreasing tumor antigenicityNovel combination therapiesImmune cell infiltrationImmune cell recruitmentTriple-negative breastType I IFN signalingActivity of etoposideSynthetic lethal strategyActivation of type I interferonDefective DNA repairType I interferon
2021
Polymerase θ Coordinates Multiple Intrinsic Enzymatic Activities during DNA Repair
Zahn KE, Jensen RB. Polymerase θ Coordinates Multiple Intrinsic Enzymatic Activities during DNA Repair. Genes 2021, 12: 1310. PMID: 34573292, PMCID: PMC8470613, DOI: 10.3390/genes12091310.Peer-Reviewed Original ResearchConceptsPolymerase θAmino acid protein productDNA double-strand break repair pathwayDouble-strand break repair pathwayTemplate-dependent DNA polymerasesDNA-dependent ATPaseDNA double-strand breaksBreak repair pathwayIntrinsic enzymatic activitySynthetic lethal strategyDouble-strand breaksDrug target candidatesDNA repair defectsDNA polymerase θSmall molecule inhibitorsPARP inhibitor resistanceHomologous recombinationDNA repairLyase functionRepair pathwaysEnzymatic functionProtein productsLethal strategiesRepair defectsBRCA-mutant cancers
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