2009
Synthesis and biological activity of α-galactosyl ceramide KRN7000 and galactosyl (α1→2) galactosyl ceramide
Veerapen N, Brigl M, Garg S, Cerundolo V, Cox L, Brenner M, Besra G. Synthesis and biological activity of α-galactosyl ceramide KRN7000 and galactosyl (α1→2) galactosyl ceramide. Bioorganic & Medicinal Chemistry Letters 2009, 19: 4288-4291. PMID: 19502056, PMCID: PMC2722241, DOI: 10.1016/j.bmcl.2009.05.095.Peer-Reviewed Original Research
2007
Blockade of NKG2D on NKT cells prevents hepatitis and the acute immune response to hepatitis B virus
Vilarinho S, Ogasawara K, Nishimura S, Lanier LL, Baron JL. Blockade of NKG2D on NKT cells prevents hepatitis and the acute immune response to hepatitis B virus. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 18187-18192. PMID: 17991774, PMCID: PMC2084318, DOI: 10.1073/pnas.0708968104.Peer-Reviewed Original ResearchConceptsHepatitis B virusHepatitis B viral infectionB virusImmune responseAcute hepatitisNKT cellsLiver injuryViral infectionCell-mediated immune responsesBlockade of NKG2DPrimary HBV infectionAcute liver injuryAcute immune responseTransgenic mouse modelPotential therapeutic targetNKG2D-ligand interactionChronic hepatitisHBV infectionAlpha-GalCerNatural killerHepatic pathologyViral antigensMouse modelTherapeutic targetHepatitisThe length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation
McCarthy C, Shepherd D, Fleire S, Stronge V, Koch M, Illarionov P, Bossi G, Salio M, Denkberg G, Reddington F, Tarlton A, Reddy B, Schmidt R, Reiter Y, Griffiths G, van der Merwe P, Besra G, Jones E, Batista F, Cerundolo V. The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation. Journal Of Experimental Medicine 2007, 204: 1131-1144. PMID: 17485514, PMCID: PMC2118584, DOI: 10.1084/jem.20062342.Peer-Reviewed Original ResearchConceptsAlpha-GalCer analoguesInvariant NKTT cell receptorAlpha-GalCerINKT cell activationHuman CD1d moleculesCell activationRecognition of lipidCell T cell receptorNKT cell activationStable immunological synapseF-channelsCD1d moleculesLipid antigensRecognition surfaceImmunological synapseSpecificity of antigen recognitionAlpha-GalactosylceramideSynapse formationConformational changesConformational differencesAntigen recognitionEngineered antibodiesLymphocytesBiological responses
2005
Stimulation of Host NKT Cells by Synthetic Glycolipid Regulates Acute Graft-versus-Host Disease by Inducing Th2 Polarization of Donor T Cells
Hashimoto D, Asakura S, Miyake S, Yamamura T, Van Kaer L, Liu C, Tanimoto M, Teshima T. Stimulation of Host NKT Cells by Synthetic Glycolipid Regulates Acute Graft-versus-Host Disease by Inducing Th2 Polarization of Donor T Cells. The Journal Of Immunology 2005, 174: 551-556. PMID: 15611282, DOI: 10.4049/jimmunol.174.1.551.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CD1Antigens, CD1dBone Marrow TransplantationEnzyme-Linked Immunosorbent AssayFemaleFlow CytometryGalactosylceramidesGlycolipidsGraft vs Host DiseaseMiceMice, KnockoutSTAT6 Transcription FactorTh2 CellsT-Lymphocyte SubsetsT-LymphocytesTrans-ActivatorsTumor Necrosis Factor-alphaConceptsHost NKT cellsDonor T cellsNKT cellsT cellsTh2 polarizationAcute GVHDAcute graftHost diseaseAlpha-GalCerAllogeneic bone marrow transplantationImmunoregulatory T-cell populationsMortality of GVHDTh2 cytokine responsesSerum TNF-alphaNKT cell ligandBone marrow transplantationSTAT6-dependent mechanismT cell populationsNKT ligandCytokine responsesMarrow transplantationIL-4Recipient miceTNF-alphaGVHD
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