2025
Novel Quinazoline Derivatives Inhibit Splicing of Fungal Group II Introns
Fedorova O, Luo M, Jagdmann G, Van Zandt M, Sisto L, Pyle A. Novel Quinazoline Derivatives Inhibit Splicing of Fungal Group II Introns. ACS Chemical Biology 2025, 20: 378-385. PMID: 39824511, PMCID: PMC11851433, DOI: 10.1021/acschembio.4c00631.Peer-Reviewed Original ResearchGroup II intronsRNA tertiary structureII intronsSelf-splicing group II intronsTertiary structureAntifungal activityDiscovery of small moleculesHigh-throughput screening effortsAntifungal efficacyHigh-affinity ligandsRNAIntronYeastEnhanced inhibitory activitySmall moleculesScreening methodologyCandidaInhibitory activityScreening effortsHuman healthActivityInhibitor classLigandStructureCompounds
2010
Inclusion of weak high-resolution X-ray data for improvement of a group II intron structure
Wang J. Inclusion of weak high-resolution X-ray data for improvement of a group II intron structure. Acta Crystallographica Section D, Structural Biology 2010, 66: 988-1000. PMID: 20823550, DOI: 10.1107/s0907444910029938.Peer-Reviewed Original Research
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