2010
Mice lacking the galanin gene show decreased sensitivity to nicotine conditioned place preference
Neugebauer NM, Henehan RM, Hales CA, Picciotto MR. Mice lacking the galanin gene show decreased sensitivity to nicotine conditioned place preference. Pharmacology Biochemistry And Behavior 2010, 98: 87-93. PMID: 21172385, PMCID: PMC3030658, DOI: 10.1016/j.pbb.2010.12.015.Peer-Reviewed Original ResearchConceptsGal-/- miceAcute nicotine administrationNicotine CPPPlace preferenceNicotine administrationRewarding effectsRole of galaninEffects of nicotineNucleus accumbens shellClass of drugsAmphetamine place preferenceDrugs of abuseGalanin signalingNeuropeptide galaninCPP chamberAlcohol drinkingNicotine rewardSignificant CPPExtracellular signal-related kinaseAccumbens shellGalanin peptideHigh doseSystem activationAlcohol preferenceSignal-related kinase
1995
The delta2-opioid receptor antagonist naltriben selectively attenuates alcohol intake in rats bred for alcohol preference
Krishnan-Sarin S, Portoghese P, Li T, Froehlich J. The delta2-opioid receptor antagonist naltriben selectively attenuates alcohol intake in rats bred for alcohol preference. Pharmacology Biochemistry And Behavior 1995, 52: 153-159. PMID: 7501658, DOI: 10.1016/0091-3057(95)00080-g.Peer-Reviewed Original ResearchConceptsAlcohol intakeOpioid antagonistDelta2-opioid receptor antagonist naltribenAlcohol preferenceNonselective opioid receptor antagonistDifferent opioid receptor typesOpioid receptor antagonistSelective opioid antagonistsDelta-2 receptorsOpioid receptor typesDelta-opioid receptorsAlcohol drinking behaviorHigh alcohol preferenceDelta 1Antagonist naltribenReceptor antagonistRodent brainNaltribenDistinct subtypesReceptor typesPharmacological propertiesIntakeAntagonistRatsReceptorsThe delta opioid receptor antagonist naltrindole attenuates both alcohol and saccharin intake in rats selectively bred for alcohol preference
Krishnan-Sarin S, Jing S, Kurtz D, Zweifel M, Portoghese P, Li T, Froehlich J. The delta opioid receptor antagonist naltrindole attenuates both alcohol and saccharin intake in rats selectively bred for alcohol preference. Psychopharmacology 1995, 120: 177-185. PMID: 7480550, DOI: 10.1007/bf02246191.Peer-Reviewed Original ResearchConceptsAlcohol intakeICI 174864Delta-opioid receptor antagonist naltrindoleAlcohol preferenceAttenuate alcohol intakeDuration of actionWater intakeDose-dependent mannerAntagonist naltrindoleAlcohol drinkingDelta receptorsDrug treatmentEffective doseIntakeDoseLonger durationSaccharin solutionGreater suppressionRatsLimited durationDurationNTISuppressionNaltrindoleAdministration
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