2023
Phototherapy Restores Deficient Type I IFN Production and Enhances Antitumor Responses in Mycosis Fungoides
Yu Z, Vieyra-Garcia P, Benezeder T, Crouch J, Kim I, O'Malley J, Devlin P, Gehad A, Zhan Q, Gudjonsson J, Sarkar M, Kahlenberg J, Gerard N, Teague J, Kupper T, LeBoeuf N, Larocca C, Tawa M, Pomahac B, Talbot S, Orgill D, Wolf P, Clark R. Phototherapy Restores Deficient Type I IFN Production and Enhances Antitumor Responses in Mycosis Fungoides. Journal Of Investigative Dermatology 2023, 144: 621-632.e1. PMID: 37716650, PMCID: PMC10922223, DOI: 10.1016/j.jid.2023.06.212.Peer-Reviewed Original ResearchType I IFNType I IFN productionI IFN expressionI IFN productionI IFNUVA therapyAntitumor responseSkin lesionsIFN productionIFN expressionMycosis fungoides skin lesionsType I IFN expressionAntigen-specific T cell activationEffective tumor clearanceType I interferon productionEnhanced antitumor responseSun-protected skinIFN response genesI interferon productionT cell activationType I IFN gene expressionIFN gene expressionTumor clearanceMycosis fungoidesEffective therapy
2021
Inborn errors of TLR3- or MDA5-dependent type I IFN immunity in children with enterovirus rhombencephalitis
Chen J, Jing H, Martin-Nalda A, Bastard P, Rivière J, Liu Z, Colobran R, Lee D, Tung W, Manry J, Hasek M, Boucherit S, Lorenzo L, Rozenberg F, Aubart M, Abel L, Su H, Palacin P, Casanova J, Zhang S. Inborn errors of TLR3- or MDA5-dependent type I IFN immunity in children with enterovirus rhombencephalitis. Journal Of Experimental Medicine 2021, 218: e20211349. PMID: 34726731, PMCID: PMC8570298, DOI: 10.1084/jem.20211349.Peer-Reviewed Original ResearchMeSH KeywordsCells, CulturedChild, PreschoolEncephalitis, ViralEnterovirusEnterovirus InfectionsFemaleFibroblastsHumansInfantInterferon alpha-2Interferon-betaInterferon-Induced Helicase, IFIH1Loss of Function MutationMaleMetabolism, Inborn ErrorsPoly I-CRhombencephalonToll-Like Receptor 3Virus ReplicationConceptsIFN-α2bVirus-induced type I IFN productionType I IFN productionLife-threatening infectionsI IFN productionCentral nervous systemPost-infection treatmentCell-intrinsic immunityLater time pointsEnterovirus infectionHuman TLR3IFN productionNervous systemTLR3Unrelated childrenViral phenotypeInborn errorsViral susceptibilityTime pointsIFIH1 variantsInfectionRhombencephalitisCell linesEV30MDA5
2020
Viral infection dampens human fetal membrane type I interferon responses triggered by bacterial LPS
Potter JA, Tong M, Aldo P, Kwon JY, Pitruzzello M, Mor G, Abrahams VM. Viral infection dampens human fetal membrane type I interferon responses triggered by bacterial LPS. Journal Of Reproductive Immunology 2020, 140: 103126. PMID: 32289593, PMCID: PMC7299810, DOI: 10.1016/j.jri.2020.103126.Peer-Reviewed Original ResearchConceptsType I IFNsMaternal-fetal interfaceI IFNsAbility of LPSMouse fetal membranesI interferonFetal membranesViral infectionMHV-68IRF-7LPS treatmentBacterial LPSType I IFN productionLow-dose LPSPrior viral infectionΓ-herpes virusMHV-68 infectionPregnant C57BL/6 miceI IFN productionType I interferonHuman fetal membranesDose LPSInnate immune strategiesC57BL/6 miceIFN production
2018
The interaction between IKKα and LC3 promotes type I interferon production through the TLR9-containing LAPosome
Hayashi K, Taura M, Iwasaki A. The interaction between IKKα and LC3 promotes type I interferon production through the TLR9-containing LAPosome. Science Signaling 2018, 11 PMID: 29717061, PMCID: PMC6462218, DOI: 10.1126/scisignal.aan4144.Peer-Reviewed Original ResearchConceptsInterferon regulatory factor 7Autophagy protein LC3Type I IFN productionI interferonI IFN productionMicrotubule-associated proteinsPutative LC3Type I interferon productionEndosomal vesiclesAutophagosome formationNoncanonical autophagyToll-like receptor 9Production of IFNStimulation of TLR9Regulatory factor 7Protein LC3Direct bindingI interferon productionIFN productionEndosomesChain 3Type I interferonKinase IKKαLC3Lap formation
2016
CD4 Receptor is a Key Determinant of Divergent HIV-1 Sensing by Plasmacytoid Dendritic Cells
O’Brien M, Manches O, Wilen C, Gopal R, Huq R, Wu V, Sunseri N, Bhardwaj N. CD4 Receptor is a Key Determinant of Divergent HIV-1 Sensing by Plasmacytoid Dendritic Cells. PLOS Pathogens 2016, 12: e1005553. PMID: 27082754, PMCID: PMC4833349, DOI: 10.1371/journal.ppat.1005553.Peer-Reviewed Original ResearchConceptsPlasmacytoid dendritic cellsAntigen presenting cellsI interferonDendritic cellsNF-κBMature dendritic cell phenotypePotent antigen presenting cellsToll-like receptor 7/9HIV-1 sensingDendritic cell phenotypeInnate immune cellsNF-κB pathwayType I interferonViral nucleic acidsIRF7 pathwayPDC activationImmune cellsPresenting cellsDisease progressionHIV virionsHIV-1IFN productionCD4 receptorInadequate maturationCell phenotype
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