Metabolism and Mode of Inhibition of Varicella-Zoster Virus by l-β-5-Bromovinyl-(2-hydroxymethyl)-(1,3-dioxolanyl)uracil Is Dependent on Viral Thymidine Kinase
Li L, Dutschman G, Gullen E, Tsujii E, Grill S, Choi Y, Chu C, Cheng Y. Metabolism and Mode of Inhibition of Varicella-Zoster Virus by l-β-5-Bromovinyl-(2-hydroxymethyl)-(1,3-dioxolanyl)uracil Is Dependent on Viral Thymidine Kinase. Molecular Pharmacology 2000, 58: 1109-1114. DOI: 10.1016/s0026-895x(24)12485-6.Peer-Reviewed Original ResearchViral thymidine kinaseHuman embryonic lungThymidine kinaseVaricella-zoster virus growthMitochondrial DNA synthesisHuman cytosolic thymidine kinaseCytosolic thymidine kinaseNucleoside analogsDeoxyuridine analogsCell growthVirus growthDNA synthesisKinaseE-5-(2-bromovinyl)-2'-deoxyuridineCell culturesInhibition of CEMMonophosphate metaboliteEmbryonic lungTriphosphate metaboliteL-configurationAntiviral activityD-configurationInhibitory mechanismCellsVaricella-zoster virus
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