2023
HIV-1 Remission: Accelerating the Path to Permanent HIV-1 Silencing
Lyons D, Kumar P, Roan N, Defechereux P, Feschotte C, Lange U, Murthy N, Sameshima P, Verdin E, Ake J, Parsons M, Nath A, Gianella S, Smith D, Kallas E, Villa T, Strange R, Mwesigwa B, O’Brien R, Nixon D, Ndhlovu L, Valente S, Ott M. HIV-1 Remission: Accelerating the Path to Permanent HIV-1 Silencing. Viruses 2023, 15: 2171. PMID: 38005849, PMCID: PMC10674359, DOI: 10.3390/v15112171.Peer-Reviewed Original Research
2019
Human APOBEC3G Prevents Emergence of Infectious Endogenous Retrovirus in Mice
Treger RS, Tokuyama M, Dong H, Salas-Briceno K, Ross SR, Kong Y, Iwasaki A. Human APOBEC3G Prevents Emergence of Infectious Endogenous Retrovirus in Mice. Journal Of Virology 2019, 93: 10.1128/jvi.00728-19. PMID: 31341050, PMCID: PMC6798113, DOI: 10.1128/jvi.00728-19.Peer-Reviewed Original ResearchConceptsToll-like receptor 7Infectious endogenous retrovirusHuman APOBEC3GAPOBEC3GHA3GEndogenous retrovirusesAntiviral restriction factorsReceptor 7Human endogenous retrovirusesTransgenic miceERV RNAsERV reactivationMiceAPOBEC3 proteinsCell-intrinsic defenseHost mechanismsPrevents emergenceRestriction factorsPermissive cellsDeleterious consequencesSubsequent disruptionRetrovirusesEctopic expressionHumansExpression
2018
ERVmap analysis reveals genome-wide transcription of human endogenous retroviruses
Tokuyama M, Kong Y, Song E, Jayewickreme T, Kang I, Iwasaki A. ERVmap analysis reveals genome-wide transcription of human endogenous retroviruses. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: 12565-12572. PMID: 30455304, PMCID: PMC6294949, DOI: 10.1073/pnas.1814589115.Peer-Reviewed Original ResearchConceptsEndogenous retrovirusesGenome-wide identificationProtein-coding sequencesLocus-specific expressionWide transcriptionHuman genomeHuman endogenous retrovirusesERV lociExpression patternsRetroviral elementsPrimary cellsPeripheral blood mononuclear cellsRange of diseasesBreast cancer tissue samplesHuman healthSystemic lupus erythematosusBlood mononuclear cellsCancer tissue samplesDisease-associated antigensCell linesRNALack of toolsWeb toolLupus erythematosusPerforin expression
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