2025
The role of the 3′-UTR of the chemokine receptor CCR2 and hnRNPA0 in regulating mRNA stability and subcellular distribution in human CD4+ T cells
Yukselten Y, Wishah H, Wang L, Sutton R. The role of the 3′-UTR of the chemokine receptor CCR2 and hnRNPA0 in regulating mRNA stability and subcellular distribution in human CD4+ T cells. Frontiers In Immunology 2025, 16: 1655273. PMID: 40909274, PMCID: PMC12405378, DOI: 10.3389/fimmu.2025.1655273.Peer-Reviewed Original ResearchConceptsCD4+ T cellsT cellsCCR2 mRNAPrimary CD4+ T cellsHuman CD4+ T cellsHIV co-receptorsChemokine receptor CCR2Immune cell migrationHIV infectionReceptor CCR2Chemokine receptorsCCR2 levelsCCR2MRNA stabilityCo-receptorProtein levelsRNA-binding proteinsChemokinesHIVHalf-lifeMRNAInfectious diseasesCCR2 activationGene expressionCell migration
2024
JAK/STAT signaling pathway affects CCR5 expression in human CD4+ T cells
Wang L, Yukselten Y, Nuwagaba J, Sutton R. JAK/STAT signaling pathway affects CCR5 expression in human CD4+ T cells. Science Advances 2024, 10: eadl0368. PMID: 38507500, PMCID: PMC10954213, DOI: 10.1126/sciadv.adl0368.Peer-Reviewed Original ResearchConceptsCD4<sup>+</sup> T cellsT cellsCCR5 expressionPrimary CD4<sup>+</sup> T cellsCD4+ T cellsHuman CD4+ T cellsHuman primary CD4<sup>+</sup> T cellsGlucocorticoid-regulated kinase 1HIV cure agendaHIV co-receptorsSignaling pathwayCCR5 levelsJAK/STAT inhibitor tofacitinibViremic patientsHIV patientsHIV infectionInhibitor tofacitinibJAK/STAT signaling pathwayCCR5Co-receptorHIVProtein levelsCCR2/CCR5Adverse effectsDown-regulation
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