2016
Gut Microbiome and Infant Health: Brain-Gut-Microbiota Axis and Host Genetic Factors.
Cong X, Xu W, Romisher R, Poveda S, Forte S, Starkweather A, Henderson W. Gut Microbiome and Infant Health: Brain-Gut-Microbiota Axis and Host Genetic Factors. The Yale Journal Of Biology And Medicine 2016, 89: 299-308. PMID: 27698614, PMCID: PMC5045139.Peer-Reviewed Original ResearchConceptsGut microbiomeNeonatal intensive care unitDysbiosis of gut microbiotaSignaling systemHost-microbial interactionsNeonatal gut microbiomeGut microbiotaEvolutionary trajectoriesHigh-risk preterm infantsHost geneticsDysbiosis patternsLong-term infant healthIntensive care unitMicrobiomePreterm infantsEarly life stressGeneticsHuman newbornsRegulation of healthCare unitNeurodevelopmental processesInfant healthHostMedication useDelivery mode
2015
A TPL2 (MAP3K8) disease-risk polymorphism increases TPL2 expression thereby leading to increased pattern recognition receptor-initiated caspase-1 and caspase-8 activation, signalling and cytokine secretion
Hedl M, Abraham C. A TPL2 (MAP3K8) disease-risk polymorphism increases TPL2 expression thereby leading to increased pattern recognition receptor-initiated caspase-1 and caspase-8 activation, signalling and cytokine secretion. Gut 2015, 65: 1799. PMID: 26215868, PMCID: PMC5106344, DOI: 10.1136/gutjnl-2014-308922.Peer-Reviewed Original ResearchConceptsCaspase-8 activationMonocyte-derived macrophagesAutocrine IL-1βIL-18 secretionHost-microbial interactionsCytokine secretionHuman monocyte-derived macrophagesHuman myeloid cellsMyeloid cellsCaspase-1Intestinal myeloid cellsPattern recognition receptorsOligomerisation domainIL-1βPrimary human myeloid cellsReal-time PCRFunctional consequencesTpl2NFκB signalingRecognition receptorsRNA expressionIntestinal immune homeostasisERKMyeloid-derived cellsJNK
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