EPS4.09The gut's role in pulmonary and extrapulmonary manifestation of cystic fibrosis
Cigana C, Delmonte G, Faccoetti A, Veschetti L, Gianferro F, Neri A, Fiorotto R, Livraghi-Butrico A, Massimino L, Ungaro F, Bragonzi A. EPS4.09The gut's role in pulmonary and extrapulmonary manifestation of cystic fibrosis. Journal Of Cystic Fibrosis 2025, 24: s52. DOI: 10.1016/j.jcf.2025.03.626.Peer-Reviewed Original ResearchWT miceCystic fibrosisHO miceDistal organsCollaborative CrossGenetically diverse Collaborative CrossInflammatory responseBarrier integrityManifestations of cystic fibrosisMouse models of CFEnteric bacteriaIncreased gut permeabilityCFTR modulator treatmentModel of CFEnhanced defense responsesGut barrier integrityImmune response pathwaysHigher bacterial loadsExtrapulmonary manifestationsSystemic inflammationChronic infectionInflammatory profileGut permeabilityGenomic toolsMicrobiological culture
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