Cholesterol and nonalcoholic fatty liver disease: Renewed focus on an old villain
Kerr T, Davidson N, Groszmann R, Iwakiri Y, Taddei T. Cholesterol and nonalcoholic fatty liver disease: Renewed focus on an old villain. Hepatology 2012, 56: 1995-1998. PMID: 23115010, PMCID: PMC3627394, DOI: 10.1002/hep.26088.Peer-Reviewed Original ResearchHMG-CoA reductasePhosphorylation of HMG-CoA reductaseExpression of cholesterol metabolism genesHMG-CoA reductase expressionDysregulated cholesterol metabolismFree cholesterolCholesterol metabolism genesHistological severity of NAFLDMetabolic genesAMP kinaseCoA reductaseLDL receptor expressionCholesterol ester hydrolaseDecreased phosphorylationDisease phenotypeLiver-related mortalitySeverity of NAFLDCholesterol metabolismEster hydrolaseCholesterol synthesisNonalcoholic fatty liver diseaseACAT-2Fatty liver diseaseSirtuin 1Receptor expressionStatin pleiotropy prevents rho kinase‐mediated intestinal epithelial barrier compromise induced by Blastocystis cysteine proteases
Mirza H, Wu Z, Teo JD, Tan KS. Statin pleiotropy prevents rho kinase‐mediated intestinal epithelial barrier compromise induced by Blastocystis cysteine proteases. Cellular Microbiology 2012, 14: 1474-1484. PMID: 22587300, DOI: 10.1111/j.1462-5822.2012.01814.x.Peer-Reviewed Original ResearchConceptsZonula occludens-1Intestinal epithelial barrier functionEpithelial barrier functionEpithelial permeabilityIntestinal infectionsFluorescein isothiocyanate-dextran fluxHuman colonic epithelial monolayersTherapeutic potentialHMG-CoA reductaseHMG-CoA reductase inhibitor simvastatinBarrier functionChronic intestinal infectionCytoskeletal F-actinIntestinal epithelial permeabilityReductase inhibitor simvastatinColonic epithelial monolayersIntestinal epithelial barrierTransepithelial resistanceTight junctional ZO-1Myosin light chain phosphorylationParasite cysteine proteasesSymptomatic patientsIntestinal pathologyCysteine proteasesBlastocystis infection
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