Mitochondrial Double‐Stranded RNA in Exosome Promotes Interleukin‐17 Production Through Toll‐Like Receptor 3 in Alcohol‐associated Liver Injury
Lee J, Shim Y, Seo W, Kim M, Choi W, Kim H, Kim Y, Yang K, Ryu T, Jeong J, Choi H, Eun H, Kim S, Mun H, Yoon J, Jeong W. Mitochondrial Double‐Stranded RNA in Exosome Promotes Interleukin‐17 Production Through Toll‐Like Receptor 3 in Alcohol‐associated Liver Injury. Hepatology 2020, 72: 609-625. PMID: 31849082, PMCID: PMC7297661, DOI: 10.1002/hep.31041.Peer-Reviewed Original ResearchConceptsAlcohol-associated liver diseaseToll-like receptor 3IL-17A productionCD4<sup>+</sup> T cellsT cellsIL-17AWT miceHepatocytes of WT miceKupffer cellsIL-1B expressionDouble-stranded RNAMitochondrial double-stranded RNAStages of alcohol-associated liver diseaseAlcohol-associated liver injuryProduction of IL-17AReceptor 3MRNA expressionToll-like receptor 3 knockoutWild-type (WT) miceToll-like receptor 3 activationInterleukin-17 productionIL-17A expressionInterleukin (IL)-17AExpression of mitochondrial genesSmall-sized RNA
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