2021
Risk of Disseminated Gonococcal Infections With Terminal Complement Blockade
Graciaa SH, Graciaa DS, Yildirim I, Chonat S. Risk of Disseminated Gonococcal Infections With Terminal Complement Blockade. Journal Of Pediatric Hematology/Oncology 2021, 44: e493-e495. PMID: 33560079, PMCID: PMC8556643, DOI: 10.1097/mph.0000000000002075.Peer-Reviewed Original ResearchConceptsTerminal complement blockadeComplement blockadeGonococcal infectionClonal hematopoietic stem cell disordersDisseminated gonococcal infectionHematopoietic stem cell disordersQuality of lifeStem cell disordersParoxysmal nocturnal hemoglobinuriaComplement protein C5Complement-mediated hemolysisProphylactic antibioticsIntravascular hemolysisAppropriate immunizationsAzithromycin resistanceCell disordersNocturnal hemoglobinuriaNeisseria gonorrhoeaeProtein C5Infection riskPatientsMonoclonal antibodiesNeisseria meningitidisBlockadeInfection
2020
Emerging treatment options for patients with high-risk myelodysplastic syndrome
Bewersdorf JP, Carraway H, Prebet T. Emerging treatment options for patients with high-risk myelodysplastic syndrome. Therapeutic Advances In Hematology 2020, 11: 2040620720955006. PMID: 33240476, PMCID: PMC7675905, DOI: 10.1177/2040620720955006.Peer-Reviewed Original ResearchAcute myeloid leukemiaMyelodysplastic syndromeHigh-risk myelodysplastic syndromeClonal hematopoietic stem cell disordersDriver mutationsCombinations of HMAsImmune checkpoint inhibitorsMinority of patientsModest survival benefitPeripheral blood cytopeniasTargetable driver mutationsHematopoietic stem cell disordersStem cell disordersDysplastic cell morphologyUnited States FoodAgent azacitidineCheckpoint inhibitorsIntensive chemotherapyOral agentsBlood cytopeniasSurvival benefitMDS patientsCombination therapyMDS treatmentTreatment options
2019
BOK promotes erythropoiesis in a mouse model of myelodysplastic syndrome
Kang SH, Perales O, Michaud M, Katz SG. BOK promotes erythropoiesis in a mouse model of myelodysplastic syndrome. Annals Of Hematology 2019, 98: 2089-2096. PMID: 31203423, PMCID: PMC6702064, DOI: 10.1007/s00277-019-03726-7.Peer-Reviewed Original ResearchConceptsUnfolded protein responseER stressPro-apoptotic membersBcl-2 familyNHD13 miceRT-qPCR analysisInduction of apoptosisProgenitor stem cellsHematopoietic progenitor cell assaysProtein responseDownstream effectorsGene knockoutMyelodysplastic syndromeCell stressProgenitor cell assaysEndoplasmic reticulumLower mean cell hemoglobin concentrationErythroid progenitorsNUP98-HOXD13 transgenic miceClonal hematopoietic stem cell disordersStem cellsSimilar overall survivalAcute myeloid leukemiaHematopoietic stem cell disordersMean cell hemoglobin concentration
2018
Immunosuppressive therapy in myelodysplastic syndromes: a borrowed therapy in search of the right place
Shallis RM, Chokr N, Stahl M, Pine AB, Zeidan AM. Immunosuppressive therapy in myelodysplastic syndromes: a borrowed therapy in search of the right place. Expert Review Of Hematology 2018, 11: 715-726. PMID: 30024293, DOI: 10.1080/17474086.2018.1503049.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsImmunosuppressive therapyMyelodysplastic syndromeImmune pathwaysManagement of MDSTreatment of MDSClonal hematopoietic stem cell disordersMeaningful clinical activityAdaptive immune pathwaysHematopoietic stem cell disordersStem cell disordersImmune dysregulationDisease coursePeripheral cytopeniasClinical benefitImmune activationTherapeutic optionsAplastic anemiaClinical activityHematologic diseasesCell disordersClinical experienceContinued clarificationLeukemic progressionTherapyPatients
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