2012
GSH or Palmitate Preserves Mitochondrial Energetic/Redox Balance, Preventing Mechanical Dysfunction in Metabolically Challenged Myocytes/Hearts From Type 2 Diabetic Mice
Tocchetti CG, Caceres V, Stanley BA, Xie C, Shi S, Watson WH, O’Rourke B, Spadari-Bratfisch RC, Cortassa S, Akar FG, Paolocci N, Aon MA. GSH or Palmitate Preserves Mitochondrial Energetic/Redox Balance, Preventing Mechanical Dysfunction in Metabolically Challenged Myocytes/Hearts From Type 2 Diabetic Mice. Diabetes 2012, 61: 3094-3105. PMID: 22807033, PMCID: PMC3501888, DOI: 10.2337/db12-0072.Peer-Reviewed Original ResearchConceptsMechanical dysfunctionReactive oxygen speciesType 2 diabetic db/db miceDiabetic db/db miceHigh glucoseType 2 diabetic patientsType 2 diabetic miceDb/db miceLower cardiac performanceLimited exercise capacityPoor glycemic controlType 2 diabetesΒ-agonist isoproterenolCardiac work demandsFatty acid palmitateExercise capacitySympathetic driveGlycemic controlDiabetic patientsDiabetic miceDb miceHeart dysfunctionPatient's inabilityMitochondrial reactive oxygen speciesHeart preparation
1992
Oxidative metabolism and mechanical function in reperfused neonatal pig heart
McGowan F, Lee F, Chen V, Downing S. Oxidative metabolism and mechanical function in reperfused neonatal pig heart. Journal Of Molecular And Cellular Cardiology 1992, 24: 831-840. PMID: 1433313, DOI: 10.1016/0022-2828(92)91097-o.Peer-Reviewed Original ResearchConceptsHr of reperfusionPalmitate oxidationNormothermic ischemiaControl valuesIsovolumic heart preparationNeonatal pig heartsPre-ischemic periodGlobal normothermic ischemiaMinutes of reperfusionOxidative metabolismNeonatal piglet heartMyocardial oxygen consumptionTotal normothermic ischemiaHr of perfusionMechanical functionHigh-energy phosphatesTotal ischemiaLactate useNeonatal myocardiumReperfusionNeonatal heartPiglet heartsHeart preparationIschemiaGlucose utilization
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