2025
GDF8 and activin A are the key negative regulators of muscle mass in postmenopausal females: a randomized phase I trial
Gonzalez Trotter D, Donahue S, Wynne C, Ali S, Parasoglou P, Boyapati A, Mohammadi K, Musser B, Meier P, Mastaitis J, Sleeman M, Glass D, Gasparino E, Trejos J, Davis J, Hirshberg B, Pordy R, Yancopoulos G, Herman G. GDF8 and activin A are the key negative regulators of muscle mass in postmenopausal females: a randomized phase I trial. Nature Communications 2025, 16: 4376. PMID: 40360471, PMCID: PMC12075688, DOI: 10.1038/s41467-025-59380-3.Peer-Reviewed Original ResearchConceptsHealthy postmenopausal femalesNegative regulator of muscle massRegulation of muscle massMultiple-dose partMultiple-dose administrationRegional body compositionPostmenopausal femalesMuscle massThigh muscle volumeDominant negative regulatorDose combinationSeverity of treatment-emergent adverse eventsPlacebo-controlled phase 1 trialActivin APresence of anti-drug antibodiesRandomized phase I trialTreatment-emergent adverse eventsBody compositionDual X-ray absorptiometrySingle-dose partPhase I trialPhase 1 trialSingle-dose administrationX-ray absorptiometryAnti-drug antibodies
2023
Measuring diet by metabolomics: a 14-d controlled feeding study of weighed food intake
Playdon M, Tinker L, Prentice R, Loftfield E, Hayden K, Van Horn L, Sampson J, Stolzenberg-Solomon R, Lampe J, Neuhouser M, Moore S. Measuring diet by metabolomics: a 14-d controlled feeding study of weighed food intake. American Journal Of Clinical Nutrition 2023, 119: 511-526. PMID: 38212160, PMCID: PMC10884612, DOI: 10.1016/j.ajcnut.2023.10.016.Peer-Reviewed Original ResearchConceptsWomen's Health InitiativeControlled feeding studyFood intakeAssociated with dietary intakeHabitually consumed foodsPotential of metabolomicsFasting serum samplesHealthy postmenopausal femalesHuman food intakeTandem mass spectrometryWeighed intakesEnd-of-studyLiquid chromatography tandem mass spectrometryHealth initiativesBeverage intakePostmenopausal femalesMetabolomics studiesDietary assessmentPartial Pearson correlationsHabitual dietMetabolite correlationsWeighing foodDietary intakeFood groupsMetabolomics
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