2023
Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis
Okuda K, Nakahara K, Ito A, Iijima Y, Nomura R, Kumar A, Fujikawa K, Adachi K, Shimada Y, Fujio S, Yamamoto R, Takasugi N, Onuma K, Osaki M, Okada F, Ukegawa T, Takeuchi Y, Yasui N, Yamashita A, Marusawa H, Matsushita Y, Katagiri T, Shibata T, Uchida K, Niu S, Lang N, Nakamura T, Zhang K, Lipton S, Uehara T. Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis. Nature Communications 2023, 14: 621. PMID: 36739439, PMCID: PMC9899281, DOI: 10.1038/s41467-023-36232-6.Peer-Reviewed Original ResearchConceptsS-nitrosylationDNA methyltransferasesEnzymatic activityGene expressionDe novo DNA methylationNovo DNA methylationAberrant S-nitrosylationProtein S-nitrosylationDNA methyltransferase 3BDNMT enzymatic activityStructure-based virtual screeningEpigenetic regulationDNA methylationCysteine residuesMethyltransferase 3BVivo cancer modelsS-adenosylAberrant upregulationNeoplastic cell proliferationHuman colonic adenomasMethylationCyclin D2Cell proliferationTumor formationDNMT3B
2021
MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function
Sugiura A, Andrejeva G, Voss K, Heintzman D, Xu X, Madden M, Ye X, Beier K, Chowdhury N, Wolf M, Young A, Greenwood D, Sewell A, Shahi S, Freedman S, Cameron A, Foerch P, Bourne T, Garcia-Canaveras J, Karijolich J, Newcomb D, Mangalam A, Rabinowitz J, Rathmell J. MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function. Immunity 2021, 55: 65-81.e9. PMID: 34767747, PMCID: PMC8755618, DOI: 10.1016/j.immuni.2021.10.011.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCytokinesDisease Models, AnimalDNA MethylationHumansInflammationInflammation MediatorsLymphocyte ActivationMechanistic Target of Rapamycin Complex 1Methylenetetrahydrofolate Dehydrogenase (NADP)MiceMice, TransgenicMutationPurinesSignal TransductionT-Lymphocytes, RegulatoryTh17 CellsConceptsRegulatory T cell differentiationPathogenic T helperInflammatory cytokine productionInflammatory disease modelsTranscription factor Foxp3Potential therapeutic targetT cell differentiationCell metabolic reprogrammingMethylenetetrahydrofolate dehydrogenase 2Metabolic checkpointT helperCytokine productionSuppressive capacityAntigenic stimulationFactor Foxp3Therapeutic targetDisease severityAberrant upregulationDisease models
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