2021
MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function
Sugiura A, Andrejeva G, Voss K, Heintzman D, Xu X, Madden M, Ye X, Beier K, Chowdhury N, Wolf M, Young A, Greenwood D, Sewell A, Shahi S, Freedman S, Cameron A, Foerch P, Bourne T, Garcia-Canaveras J, Karijolich J, Newcomb D, Mangalam A, Rabinowitz J, Rathmell J. MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function. Immunity 2021, 55: 65-81.e9. PMID: 34767747, PMCID: PMC8755618, DOI: 10.1016/j.immuni.2021.10.011.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCytokinesDisease Models, AnimalDNA MethylationHumansInflammationInflammation MediatorsLymphocyte ActivationMechanistic Target of Rapamycin Complex 1Methylenetetrahydrofolate Dehydrogenase (NADP)MiceMice, TransgenicMutationPurinesSignal TransductionT-Lymphocytes, RegulatoryTh17 CellsConceptsRegulatory T cell differentiationPathogenic T helperInflammatory cytokine productionInflammatory disease modelsTranscription factor Foxp3Potential therapeutic targetT cell differentiationCell metabolic reprogrammingMethylenetetrahydrofolate dehydrogenase 2Metabolic checkpointT helperCytokine productionSuppressive capacityAntigenic stimulationFactor Foxp3Therapeutic targetDisease severityAberrant upregulationDisease models
2018
mTOR Complex 1 Signaling Regulates the Generation and Function of Central and Effector Foxp3+ Regulatory T Cells
Sun I, Oh M, Zhao L, Patel C, Arwood M, Xu W, Tam A, Blosser R, Wen J, Powell J. mTOR Complex 1 Signaling Regulates the Generation and Function of Central and Effector Foxp3+ Regulatory T Cells. The Journal Of Immunology 2018, 201: 481-492. PMID: 29884702, PMCID: PMC6089237, DOI: 10.4049/jimmunol.1701477.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD8-Positive T-LymphocytesCell DifferentiationFemaleForkhead Transcription FactorsImmunologic MemoryInducible T-Cell Co-Stimulator ProteinLymphocyte ActivationMaleMechanistic Target of Rapamycin Complex 1MiceProgrammed Cell Death 1 ReceptorRegulatory-Associated Protein of mTORSignal TransductionT-Lymphocytes, RegulatoryConceptsT cell activationT cellsCentral TregsGenetic deletionCell activationRegulatory T cell differentiationGeneration of TregsRegulatory T cellsEffector T cellsMemory-like phenotypeT cell differentiationInhibition of mTORSpare respiratory capacityEffector TregsRole of mTORPD-1Treg functionImmune microenvironmentMemory TregsTregsPharmacologic inhibitionDecreased expressionMammalian targetPharmacologic inhibitorsMTOR activity
2012
The Role of Gr1+ Cells after Anti-CD20 Treatment in Type 1 Diabetes in Nonobese Diabetic Mice
Hu C, Du W, Zhang X, Wong FS, Wen L. The Role of Gr1+ Cells after Anti-CD20 Treatment in Type 1 Diabetes in Nonobese Diabetic Mice. The Journal Of Immunology 2012, 188: 294-301. PMID: 22140261, PMCID: PMC4361178, DOI: 10.4049/jimmunol.1101590.Peer-Reviewed Original ResearchConceptsType 1 diabetesT cell functionNOD miceCD8 T cell functionRegulatory T cell differentiationAnti-CD20 treatmentPancreatic islet autoimmunityB-cell depletionCell contact-dependent mannerNonobese diabetic (NOD) miceCell functionT cell differentiationContact-dependent mannerDiabetogenic CD4Islet autoimmunityNovel immunotherapiesIL-10Immune toleranceDiabetic miceAutoimmune diseasesCell depletionImmunoregulatory functionsDiabetesMiceDependent manner
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