GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway
Hoppe N, Harrison S, Hwang S, Chen Z, Karelina M, Deshpande I, Suomivuori C, Palicharla V, Berry S, Tschaikner P, Regele D, Covey D, Stefan E, Marks D, Reiter J, Dror R, Evers A, Mukhopadhyay S, Manglik A. GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. Nature Structural & Molecular Biology 2024, 31: 667-677. PMID: 38326651, PMCID: PMC11221913, DOI: 10.1038/s41594-024-01223-8.Peer-Reviewed Original ResearchConceptsCryogenic-electron microscopy structuresHedgehog pathwayTransmembrane helix 6Gpr161 functionsCiliary accumulationHeterotrimeric GsGpr161C-terminusHedgehog signalingCAMP SignalingPrimary ciliaHelix 6Signaling pathwayLoop 2Gs-mediated signalingStructural featuresExtracellular loop 2HedgehogLigand pocketGli2PathwayGs couplingSterolsMutantsSignal
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