2011
A Primate Herpesvirus Uses the Integrator Complex to Generate Viral MicroRNAs
Cazalla D, Xie M, Steitz JA. A Primate Herpesvirus Uses the Integrator Complex to Generate Viral MicroRNAs. Molecular Cell 2011, 43: 982-992. PMID: 21925386, PMCID: PMC3176678, DOI: 10.1016/j.molcel.2011.07.025.Peer-Reviewed Original ResearchConceptsEnd processing signalsHerpesvirus saimiriMature viral miRNAsPre-miRNA hairpinsCis-acting elementsMarmoset T cellsIntegrator complexAGO proteinsMiRNA biogenesisMicroprocessor complexU RNAExportin-5Noncoding RNAsViral miRNAsProcessing assaysHost miRNAsDeep sequencingViral noncoding RNAsProtein componentsComplex cleavesHairpin structureHSURsPrimate herpesvirusesMiRNAsRNA
1997
Identification of V(D)J recombination coding end intermediates in normal thymocytes 11Edited by K. Yamamoto
Livák F, Schatz D. Identification of V(D)J recombination coding end intermediates in normal thymocytes 11Edited by K. Yamamoto. Journal Of Molecular Biology 1997, 267: 1-9. PMID: 9096202, DOI: 10.1006/jmbi.1996.0834.Peer-Reviewed Original ResearchConceptsRecombination signal sequencesNormal lymphoid precursorsSignal endsJ alpha genesPre-B cell linesGene rearrangement processDouble-strand breaksNormal murine thymocytesSignal sequenceLymphoid precursorsK. YamamotoAlpha geneFirst direct demonstrationHairpin structureLow abundanceStrand breaksGene segmentsCell linesAntigen receptorMurine thymocytesRecombinationDirect demonstrationVivoJoint formationNormal thymocytes
1981
The spontaneous insertion of proteins into and across membranes: The helical hairpin hypothesis
Engelman D, Steitz T. The spontaneous insertion of proteins into and across membranes: The helical hairpin hypothesis. Cell 1981, 23: 411-422. PMID: 7471207, DOI: 10.1016/0092-8674(81)90136-7.Peer-Reviewed Original ResearchConceptsMembrane proteinsSecreted proteinsIntegral membrane proteinsHydrophobic leader peptideSecretion of proteinsHelical hairpinSpecific membrane receptorsPolypeptide sequenceSecond helixLeader peptideTransport proteinsLipid environmentTerminal helixN-terminusSpontaneous insertionMembrane receptorsHairpin structurePolypeptide structureProteinHelixHairpinHydrophobic interiorOnly alphaNonpolar sequencesHydrophobic portion
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