2017
Site- and Stereoselective Chemical Editing of Thiostrepton by Rh-Catalyzed Conjugate Arylation: New Analogues and Collateral Enantioselective Synthesis of Amino Acids
Key HM, Miller SJ. Site- and Stereoselective Chemical Editing of Thiostrepton by Rh-Catalyzed Conjugate Arylation: New Analogues and Collateral Enantioselective Synthesis of Amino Acids. Journal Of The American Chemical Society 2017, 139: 15460-15466. PMID: 28975793, PMCID: PMC5736372, DOI: 10.1021/jacs.7b08775.Peer-Reviewed Original ResearchConceptsComplex moleculesSite-selective catalysisComplex molecular settingsComplex natural productsSite-selective modificationPotassium saltNew analoguesApplication of RhFunctional group toleranceEnantioselective catalysisSelective functionalizationCatalyst systemAnalogous reactionStereoselective functionalizationEnantioselective synthesisGroup toleranceNatural productsActive moleculesPotent antibacterial propertiesDehydroalanine residuesBiological testingAmino estersHigh stereoselectivityAntibacterial propertiesMolecular setting
2006
Organometallic Complexes Containing 17-Ethynyl-17β-hydroxyandrost-4-en-3-one and Related Ethynyl Steroids
Stockland R, Kohler M, Guzei I, Kastner M, Bawiec J, Labaree D, Hochberg R. Organometallic Complexes Containing 17-Ethynyl-17β-hydroxyandrost-4-en-3-one and Related Ethynyl Steroids. Organometallics 2006, 25: 2475-2485. DOI: 10.1021/om051064r.Peer-Reviewed Original ResearchJ CPEthynyl steroidsElectron-withdrawing groupsOrganometallic complexesPhosphine donorsEthynyl fragmentOrganic fragmentsChemical shiftsDonor abilityFree phosphineGold complexesAlkyne moietyMolecular structureAnalogous reactionNMR spectraTransition metalsIntractable mixturesPhosphineBroad signalSharp signalTitle compoundCompoundsPhosphorus donorsSteroid compoundsRepresentative examples
1998
Modification of Platinum(II) Antitumor Complexes with Sulfur Ligands. 2. Reactivity and Nucleotide Binding Properties of Cationic Complexes of the Types [PtCl(diamine)(L)]NO3 and [{PtCl(diamine)}2(L-L)](NO3)2 (L = Monofunctional Thiourea Derivative; L-L = Bifunctional Thiourea Derivative) in Relation to Their Cytotoxicity
Bierbach U, Roberts J, Farrell N. Modification of Platinum(II) Antitumor Complexes with Sulfur Ligands. 2. Reactivity and Nucleotide Binding Properties of Cationic Complexes of the Types [PtCl(diamine)(L)]NO3 and [{PtCl(diamine)}2(L-L)](NO3)2 (L = Monofunctional Thiourea Derivative; L-L = Bifunctional Thiourea Derivative) in Relation to Their Cytotoxicity. Inorganic Chemistry 1998, 37: 717-723. DOI: 10.1021/ic970421q.Peer-Reviewed Original ResearchAntitumor complexesAqueous solution chemistryDinuclear complexes 3Dinuclear compound 3NMR chemical shiftsN-type conformationComplexes 3Thiourea ligandsCationic complexesSulfur ligandsNMR spectroscopyChemical shiftsSolution chemistryDinuclear adductsIntramolecular disproportionationAnalogous reactionCompound 3Aqueous solutionMonofunctional adductsBifunctional adductsRate of hydrolysisAdductsBinding propertiesChemistryCytotoxicity data
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