2025
Publication and data sharing of completed NCI cooperative group trials.
Cueto L, Huang S, Ghali F, Abgafe V, Ubachukwu T, Winer E, Ross J, Gross C. Publication and data sharing of completed NCI cooperative group trials. Journal Of Clinical Oncology 2025, 43: 11023-11023. DOI: 10.1200/jco.2025.43.16_suppl.11023.Peer-Reviewed Original ResearchCooperative group trialsIndividual patient dataPhase III trialsYear of study completionPrimary outcomeIII trialsGroup trialAvailability of individual patient dataEastern Cooperative Oncology GroupStudy completionAnalysis of phase III trialsCooperative Oncology GroupClinical trial dataPatient dataCooperative groupsPrimary outcome dataPhase IIOncology GroupNRG OncologySubgroup analysisOnline archivesNIH trialData sharingPrimary outcome findingsOutcome data
2021
Machine-learning model derived gene signature predictive of paclitaxel survival benefit in gastric cancer: results from the randomised phase III SAMIT trial
Sundar R, Kumarakulasinghe N, Chan Y, Yoshida K, Yoshikawa T, Miyagi Y, Rino Y, Masuda M, Guan J, Sakamoto J, Tanaka S, Tan A, Hoppe M, Jeyasekharan A, Ng C, De Simone M, Grabsch H, Lee J, Oshima T, Tsuburaya A, Tan P. Machine-learning model derived gene signature predictive of paclitaxel survival benefit in gastric cancer: results from the randomised phase III SAMIT trial. Gut 2021, 71: 676-685. PMID: 33980610, PMCID: PMC8921574, DOI: 10.1136/gutjnl-2021-324060.Peer-Reviewed Original ResearchConceptsDisease free survivalValidation cohortGastric cancerGene signatureSurvival benefitPac-SensitiveNo survival differenceSelection of patientsGC trialsFree survivalPaclitaxel chemotherapyCurative surgeryMetastatic patientsPredictive biomarkersTraining cohortSurvival differencesIndependent cohortNanoString panelGC patientsPaclitaxelPatientsNanoString profilingCohortGroup trialUFT
2014
Adult Cancer Clinical Trials That Fail to Complete: An Epidemic?
Stensland K, McBride R, Latif A, Wisnivesky J, Hendricks R, Roper N, Boffetta P, Hall S, Oh W, Galsky M. Adult Cancer Clinical Trials That Fail to Complete: An Epidemic? Journal Of The National Cancer Institute 2014, 106: dju229. PMID: 25190726, DOI: 10.1093/jnci/dju229.Peer-Reviewed Original ResearchConceptsClinical trialsCancer clinical trialsNational Cancer InstituteCumulative incidence of failureCooperative group trialsStandard therapeutic approachClinical drug developmentIncidence of failureCumulative incidenceEligible patientsPreclinical discoveryTherapeutic approachesCancer therapeuticsCancer InstituteCancer biologyCancerPatientsNew therapeuticsTherapeutic targetGroup trialClinical trial enterpriseTrialsDrug to marketDrug developmentClinical trial system
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