2023
Oligomeric organization of membrane proteins from native membranes at nanoscale spatial and single-molecule resolution
Walker G, Brown C, Ge X, Kumar S, Muzumdar M, Gupta K, Bhattacharyya M. Oligomeric organization of membrane proteins from native membranes at nanoscale spatial and single-molecule resolution. Nature Nanotechnology 2023, 19: 85-94. PMID: 38012273, PMCID: PMC10981947, DOI: 10.1038/s41565-023-01547-4.Peer-Reviewed Original ResearchMembrane proteinsNative membranesOligomeric organizationDiverse membrane proteinsMembrane protein biologyNative cell membranesTarget membrane proteinsNative membrane environmentSingle-molecule resolutionSingle-molecule platformReceptor tyrosine kinasesOligomeric distributionNative nanodiscsOligomerization statusProtein biologySmall GTPaseGrowth factor bindingMembrane environmentOligomeric assembliesTyrosine kinaseCritical regulatorOncogenic mutationsCell membraneProteinMembrane
2010
Structural Basis for Negative Cooperativity in Growth Factor Binding to an EGF Receptor
Alvarado D, Klein DE, Lemmon MA. Structural Basis for Negative Cooperativity in Growth Factor Binding to an EGF Receptor. Cell 2010, 142: 568-579. PMID: 20723758, PMCID: PMC2925043, DOI: 10.1016/j.cell.2010.07.015.Peer-Reviewed Original ResearchConceptsEGFR extracellular regionEpidermal growth factor receptorExtracellular regionEGF receptorDifferent signaling propertiesLigand-binding eventsLigand-induced dimerizationIntracellular tyrosine kinase domainNegative cooperativityCooperative ligand bindingTyrosine kinase domainAllosteric regulationEGF-binding sitesKinase domainFactor bindingGrowth factor receptorGrowth factor bindingStructural basisLigand bindingEGFR ligandsSignaling propertiesFactor receptorReduced affinityAsymmetric dimerUnoccupied sites
1983
Ontogenesis and characteristics of epidermal growth factor receptors in human placenta
Carson S, Chase R, Ulep E, Scommegna A, Benveniste R. Ontogenesis and characteristics of epidermal growth factor receptors in human placenta. American Journal Of Obstetrics And Gynecology 1983, 147: 932-939. PMID: 6316790, DOI: 10.1016/0002-9378(83)90249-1.Peer-Reviewed Original ResearchConceptsEpidermal growth factor receptorGrowth factor receptorEpidermal growth factorNumber of receptorsNormal gestationGrowth factorFactor receptorFetal developmentSimilar gestational ageWeeks of gestationThird trimester placentasSpecific epidermal growth factor receptorGestational ageEpidermal growth factor bindingCell membrane preparationsReceptor occupancyGestationFurther evaluationHuman placentaNormal tissuesGrowth factor bindingReceptorsPlacentaScatchard analysisCell types
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