2018
Bergmann glial Sonic hedgehog signaling activity is required for proper cerebellar cortical expansion and architecture
Cheng FY, Fleming JT, Chiang C. Bergmann glial Sonic hedgehog signaling activity is required for proper cerebellar cortical expansion and architecture. Developmental Biology 2018, 440: 152-166. PMID: 29792854, PMCID: PMC6014626, DOI: 10.1016/j.ydbio.2018.05.015.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstrocytesCell DifferentiationCell DivisionCell ProliferationCells, CulturedCerebellar CortexCerebellar NeoplasmsCerebellumDevelopmental DisabilitiesHedgehog ProteinsMiceNervous System MalformationsNeural Stem CellsNeurogliaNeuronsPurkinje CellsSignal TransductionWnt Signaling PathwayConceptsCerebellar granule neuron precursorsBergmann gliaDay of ablationSevere cerebellar hypoplasiaCentral nervous system architectureCGNP proliferationGranule neuron precursorsRole of ShhBergmann glial fibersNervous system architectureCerebellar hypoplasiaGlial fibersCortical expansionPurkinje cellsNeuron precursorsGlial networkSpecific ablationGliaNeural tissueNeuronal specificationSignificant decreaseCerebellar sizeShh pathwayMutant cerebellumHh pathway
2012
Widespread Contribution of Gdf7 Lineage to Cerebellar Cell Types and Implications for Hedgehog-Driven Medulloblastoma Formation
Cheng FY, Huang X, Sarangi A, Ketova T, Cooper MK, Litingtung Y, Chiang C. Widespread Contribution of Gdf7 Lineage to Cerebellar Cell Types and Implications for Hedgehog-Driven Medulloblastoma Formation. PLOS ONE 2012, 7: e35541. PMID: 22539980, PMCID: PMC3335071, DOI: 10.1371/journal.pone.0035541.Peer-Reviewed Original ResearchConceptsSonic hedgehog-driven medulloblastomaGlutamatergic granule neuronsBergmann glial cellsCentral nervous systemChoroid plexus epithelial cellsCell typesGenetic fate-mapping studiesGlial cell typesChoroid plexus epitheliumUnipolar brush cellsCerebellar granule neuron precursorsPlexus epithelial cellsGranule neuron precursorsGABAergic interneuronsNeural cell typesGlial cellsPurkinje neuronsNervous systemGranule neuronsRoof plateWhite matterPlexus epitheliumBrush cellsNeuron precursorsSonic hedgehog (Shh) signalingImpaired motor coordination and disrupted cerebellar architecture in Fgfr1 and Fgfr2 double knockout mice
Smith K, Williamson TL, Schwartz ML, Vaccarino FM. Impaired motor coordination and disrupted cerebellar architecture in Fgfr1 and Fgfr2 double knockout mice. Brain Research 2012, 1460: 12-24. PMID: 22578469, PMCID: PMC3361544, DOI: 10.1016/j.brainres.2012.04.002.Peer-Reviewed Original ResearchConceptsFibroblast growth factor receptorHuman GFAP promoterInner granule cell layerDKO miceGranule cell numberGranule cell progenitorsRadial glial stem cellsMidline glial structuresImpaired motor coordinationCerebellar sizeGranule cell layerDouble knockout miceGlial precursor cellsGlial stem cellsCell numberGranule neuron precursorsGrowth factor receptorGABA interneuronsGranule cell migrationCerebral cortexExternal granular layerMolecular layerMotor coordinationGranule cellsKnockout mice
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