2015
Dynamin 2 regulates biphasic insulin secretion and plasma glucose homeostasis
Fan F, Ji C, Wu Y, Ferguson SM, Tamarina N, Philipson LH, Lou X. Dynamin 2 regulates biphasic insulin secretion and plasma glucose homeostasis. Journal Of Clinical Investigation 2015, 125: 4026-4041. PMID: 26413867, PMCID: PMC4639984, DOI: 10.1172/jci80652.Peer-Reviewed Original ResearchConceptsDynamin 2Glucose-stimulated insulin secretionΒ-cellsExocytosis-endocytosis couplingControl β-cellsMutant β-cellsCell surface expansionF-actin remodelingInsulin granule exocytosisEndocytic intermediatesMembrane fissionInsulin granule recruitmentPancreatic β-cell dysfunctionPlasma membraneActin filamentsBiphasic insulin secretionInsulin granulesGene ablationΒ-cell dysfunctionGranule recruitmentGlucose homeostasisBlood glucose homeostasisEndocytosisGranule exocytosisEssential role
2009
The Strength of T Cell Receptor Signal Controls the Polarization of Cytotoxic Machinery to the Immunological Synapse
Jenkins M, Tsun A, Stinchcombe J, Griffiths G. The Strength of T Cell Receptor Signal Controls the Polarization of Cytotoxic Machinery to the Immunological Synapse. Immunity 2009, 31: 621-631. PMID: 19833087, PMCID: PMC2791175, DOI: 10.1016/j.immuni.2009.08.024.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DegranulationCell PolarityCentrosomeCytoplasmic GranulesCytotoxicity, ImmunologicExtracellular Signal-Regulated MAP KinasesFemaleImmunological SynapsesMiceMice, Inbred C57BLMicroscopy, Electron, TransmissionOvalbuminPeptide FragmentsPhosphorylationReceptors, Antigen, T-CellSignal Transductionsrc-Family KinasesT-Lymphocytes, CytotoxicConceptsCytotoxic T lymphocytesCentral supramolecular activation complexT cell receptorT cell receptor signalingStrength of T cell receptor signalingImmunological synapseLytic granulesSupramolecular activation complexSecretion of lytic granulesLow-avidity interactionsGranule deliveryTarget cell deathCytotoxic machineryT lymphocytesGranule recruitmentGranule polarizationCentrosome polarizationReceptor signalingHigh-avidity interactionsPolar centrosomesCentrosomeCell deathIntracellular signalingSynapse
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