2019
Loss of ARPC1B impairs cytotoxic T lymphocyte maintenance and cytolytic activity
Randzavola L, Strege K, Juzans M, Asano Y, Stinchcombe J, Gawden-Bone C, Seaman M, Kuijpers T, Griffiths G. Loss of ARPC1B impairs cytotoxic T lymphocyte maintenance and cytolytic activity. Journal Of Clinical Investigation 2019, 129: 5600-5614. PMID: 31710310, PMCID: PMC6877333, DOI: 10.1172/jci129388.Peer-Reviewed Original ResearchConceptsCD8 cytotoxic T lymphocytesLoss of CD8+ T cellsCD8+ T cell countsCD8+ T cellsViral infectionSymptoms of immune dysregulationT-cell countsRecurrent viral infectionsProlonged viral infectionCytotoxic T lymphocytesF-actinAdaptive immune responsesSecretion of lytic granulesActin-related protein 2/3Polarized secretion of lytic granulesT cell signalingTarget cell deathCTL cytotoxicityCTL activityF-actin networkCombined immunodeficiencyImmune dysregulationT cellsCytolytic activityT lymphocytes
2009
The Strength of T Cell Receptor Signal Controls the Polarization of Cytotoxic Machinery to the Immunological Synapse
Jenkins M, Tsun A, Stinchcombe J, Griffiths G. The Strength of T Cell Receptor Signal Controls the Polarization of Cytotoxic Machinery to the Immunological Synapse. Immunity 2009, 31: 621-631. PMID: 19833087, PMCID: PMC2791175, DOI: 10.1016/j.immuni.2009.08.024.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DegranulationCell PolarityCentrosomeCytoplasmic GranulesCytotoxicity, ImmunologicExtracellular Signal-Regulated MAP KinasesFemaleImmunological SynapsesMiceMice, Inbred C57BLMicroscopy, Electron, TransmissionOvalbuminPeptide FragmentsPhosphorylationReceptors, Antigen, T-CellSignal Transductionsrc-Family KinasesT-Lymphocytes, CytotoxicConceptsCytotoxic T lymphocytesCentral supramolecular activation complexT cell receptorT cell receptor signalingStrength of T cell receptor signalingImmunological synapseLytic granulesSupramolecular activation complexSecretion of lytic granulesLow-avidity interactionsGranule deliveryTarget cell deathCytotoxic machineryT lymphocytesGranule recruitmentGranule polarizationCentrosome polarizationReceptor signalingHigh-avidity interactionsPolar centrosomesCentrosomeCell deathIntracellular signalingSynapse
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