2011
Comparative Effectiveness of Aminoglycosides, Polymyxin B, and Tigecycline for Clearance of Carbapenem-Resistant Klebsiella pneumoniae from Urine
Satlin MJ, Kubin CJ, Blumenthal JS, Cohen AB, Furuya EY, Wilson SJ, Jenkins SG, Calfee DP. Comparative Effectiveness of Aminoglycosides, Polymyxin B, and Tigecycline for Clearance of Carbapenem-Resistant Klebsiella pneumoniae from Urine. Antimicrobial Agents And Chemotherapy 2011, 55: 5893-5899. PMID: 21968368, PMCID: PMC3232750, DOI: 10.1128/aac.00387-11.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAminoglycosidesAnti-Bacterial AgentsCarbapenemsCohort StudiesDrug Resistance, BacterialFemaleHumansKlebsiella InfectionsKlebsiella pneumoniaeMaleMicrobial Sensitivity TestsMiddle AgedMinocyclinePolymyxin BRetrospective StudiesTigecyclineTreatment OutcomeUrinary Tract InfectionsUrineYoung AdultConceptsCarbapenem-resistant Klebsiella pneumoniaePolymyxin BCRKP bacteriuriaMicrobiologic clearanceUntreated cohortHealth care-associated urinary tract infectionsClearance rateKlebsiella pneumoniaeRetrospective cohort studyUrinary tract infectionNew York Presbyterian HospitalCohort studyTract infectionsUrine cultureAntimicrobial therapyAppropriate followCommon causeActive agentsMultiple active agentsTigecyclineComparative effectivenessMultivariate analysisCohortGram-negative activityAminoglycosides
2000
Block of the α9 nicotinic receptor by ototoxic aminoglycosides
Rothlin C, Katz E, Verbitsky M, Vetter D, Heinemann S, Elgoyhen A. Block of the α9 nicotinic receptor by ototoxic aminoglycosides. Neuropharmacology 2000, 39: 2525-2532. PMID: 11044724, DOI: 10.1016/s0028-3908(00)00056-3.Peer-Reviewed Original ResearchConceptsAlpha9 nicotinic acetylcholine receptorConcentration of acetylcholineNicotinic acetylcholine receptorsOrgan of CortiOuter hair cellsConcentration-dependent mannerEfferent functionCholinergic receptorsOtotoxic aminoglycosidesNicotinic receptorsAcetylcholine receptorsNon-competitive typeAcetylcholineHair cellsAminoglycosidesGentamicinXenopus laevis oocytesReceptorsAminoglycoside antibioticsReversible actionAlpha9Rank orderPresent studyAntagonistic effectLaevis oocytes
1998
Further evidence against the use of aminoglycosides in cirrhotic patients
García–Tsao G. Further evidence against the use of aminoglycosides in cirrhotic patients. Gastroenterology 1998, 114: 612-613. PMID: 9496958, DOI: 10.1016/s0016-5085(98)70551-7.Commentaries, Editorials and Letters
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