2020
Generation of pralatrexate resistant T‐cell lymphoma lines reveals two patterns of acquired drug resistance that is overcome with epigenetic modifiers
Scotto L, Kinahan C, Casadei B, Mangone M, Douglass E, Murty VV, Marchi E, Ma H, George C, Montanari F, Califano A, O'Connor OA. Generation of pralatrexate resistant T‐cell lymphoma lines reveals two patterns of acquired drug resistance that is overcome with epigenetic modifiers. Genes Chromosomes And Cancer 2020, 59: 639-651. PMID: 32614991, PMCID: PMC7540375, DOI: 10.1002/gcc.22884.Peer-Reviewed Original ResearchConceptsDihydrofolate reductaseResistant cell linesGene expression profilesCell linesT-cell lymphoma lineAntifolate pharmacologyEpigenetic modifiersExpression analysisGene expressionExpression profilesMechanistic basisT-cell selectivityParental H9 cellsIncreases expressionT-cell lymphomaSTAT5 phosphorylationMolecular targetsGene amplificationConcentration-dependent fashionLymphoma linesH9 cellsDrug resistancePutative mechanismsCellsPutative biomarkers
1992
Comparison of enzyme-linked immunosorbent and indirect immunofluorescence assays for the detection of human T-cell lymphotropic virus type-I antibodies in sera from rural Haiti
Grant W, Bia F, Chacko T, Jean-Baptiste M, Griffith B. Comparison of enzyme-linked immunosorbent and indirect immunofluorescence assays for the detection of human T-cell lymphotropic virus type-I antibodies in sera from rural Haiti. Diagnostic Microbiology And Infectious Disease 1992, 15: 121-124. PMID: 1572136, DOI: 10.1016/0732-8893(92)90034-q.Peer-Reviewed Original ResearchConceptsWestern blotHuman T-cell lymphotropic virus type IHuman T-cell lymphotropic virusEnzyme immunoassayRural HaitiLymphotropic virus type IRural Haitian populationUninfected H9 cellsPrevalence of HTLVMT-2 cellsPositive samplesEnzyme-linked immunosorbentVirus type IAvailable enzyme immunoassayIndirect immunofluorescence assaysNeurologic diseaseLymphotropic virusH9 cellsHealthy individualsIndirect immunofluorescenceImmunofluorescence assaysSerum samplesHaitian populationSerumHTLV
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