2024
Hydrogen sulfide produced by the gut microbiota impairs host metabolism via reducing GLP-1 levels in male mice
Qi Q, Zhang H, Jin Z, Wang C, Xia M, Chen B, Lv B, Peres Diaz L, Li X, Feng R, Qiu M, Li Y, Meseguer D, Zheng X, Wang W, Song W, Huang H, Wu H, Chen L, Schneeberger M, Yu X. Hydrogen sulfide produced by the gut microbiota impairs host metabolism via reducing GLP-1 levels in male mice. Nature Metabolism 2024, 6: 1601-1615. PMID: 39030389, DOI: 10.1038/s42255-024-01068-x.Peer-Reviewed Original ResearchConceptsHost metabolismGLP-1 productionGut microbiotaUnfolded protein responseMicrobiota-derived metabolitesIntestinal L cellsInhibit mitochondrial respirationDiet-induced metabolic disordersGut hormone glucagon-like peptide 1Hormone glucagon-like peptide 1Intestinal symbiontsProtein responseGLP-1Male miceGLP-1 secretionMitochondrial respirationGene expressionL cellsGutGlucagon-like peptide 1Production of hydrogen sulfideMicrobiotaPathogenesis of metabolic syndromeGLP-1 levelsDesulfovibrio
2020
Association of a glucagon‐like peptide‐1 receptor gene variant with glucose response to a mixed meal
Mashayekhi M, Wilson JR, Jafarian‐Kerman S, Nian H, Yu C, Shuey MM, Luther JM, Brown NJ. Association of a glucagon‐like peptide‐1 receptor gene variant with glucose response to a mixed meal. Diabetes Obesity And Metabolism 2020, 23: 281-286. PMID: 33001556, PMCID: PMC8142152, DOI: 10.1111/dom.14216.Peer-Reviewed Original ResearchConceptsGlucagon-like peptide-1Endogenous glucagon-like peptide-1DPP-4 inhibitor sitagliptinDipeptidyl peptidase-4 inhibitorsType 2 diabetes mellitusIntact GLP-1 levelsMixed-meal studyGLP-1 levelsPostprandial glucose excursionsPeptidase-4 inhibitorsDPP-4 inhibitionMetabolic responseGLP-1 receptorReceptor gene variantsSitagliptin treatmentDiabetes mellitusMeal studyPostprandial glucoseInhibitor sitagliptinGlucose excursionsMixed mealPeptide-1Glucose responseGenotype groupsGene variants
2018
Impaired Beta-Cell Compensation and Glucose Effectiveness in Insulin Resistant, Nondiabetic South Asians
SEDMAK C, GREWAL S, SIKDER S, GLICKSMAN M, MSZAR R, CHEN E, RABEL A, MUNIYAPPA R. Impaired Beta-Cell Compensation and Glucose Effectiveness in Insulin Resistant, Nondiabetic South Asians. Diabetes 2018, 67 DOI: 10.2337/db18-251-lb.Peer-Reviewed Original ResearchMixed meal testBeta-cell compensationB cell responsesInsulin sensitivityInsulin resistanceDisposition indexMuscle insulin sensitivity indexInsulin clearanceType 2 diabetes mellitusSouth AsiansGlucose effectivenessSurrogate indexGLP-1 levelsGlucose tolerance testPancreatic B-cell responseInsulin sensitivity indexOverall insulin sensitivityBeta-cell functionInsulin-mediated glucose disposalIntravenous glucose tolerance testIncretin levelsMeal testC-peptideClinical centersTolerance test
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