Mifepristone Treatment of Cushing’s Syndrome in a Pediatric Patient
Banerjee R, Marina N, Katznelson L, Feldman B. Mifepristone Treatment of Cushing’s Syndrome in a Pediatric Patient. 2015, 136: e1377-e1381. PMID: 26459648, DOI: 10.1542/peds.2015-0684.Peer-Reviewed Original ResearchConceptsCushing's syndromeMifepristone treatmentPediatric patientsMedical treatment of CSPatients died of progressionPreexisting type 1 diabetesTreatment of Cushing's syndromeHormone secreting tumorsOral potassium replacementMetastatic neuroendocrine carcinomaGlucocorticoid receptor antagonismGlucocorticoid receptor antagonistEffects of hypercortisolismTreatment of CSLimited life expectancyPoor functional statusType 1 diabetesEctopic CSDose escalationSignificant adverse effectsNeuroendocrine carcinomaRadiation therapyPatient diedSecreting tumorsReceptor antagonism
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