2019
Amplification of a broad transcriptional program by a common factor triggers the meiotic cell cycle in mice
Kojima M, de Rooij D, Page D. Amplification of a broad transcriptional program by a common factor triggers the meiotic cell cycle in mice. ELife 2019, 8: e43738. PMID: 30810530, PMCID: PMC6392498, DOI: 10.7554/elife.43738.Peer-Reviewed Original ResearchConceptsInitiation of meiosisMeiotic cell cycleMeiotic initiationTranscriptional programsCell cycleGerm cell-specific genesG1-S cell cycle transitionCell-specific genesCell cycle transitionGene expression programsMulticellular organismsTranscriptional networksDNA replicationGerm lineRobust amplificationMeiosis I.G1-SGenesExpression programsMeiosisStra8GermAmplificationMiceCells
2018
Suppression of dsRNA response genes and innate immunity following Oct4, Stella, and Nanos2 overexpression in mouse embryonic fibroblasts
Farshchian M, Matin M, Armant O, Geerts D, Dastpak M, Nakhaei-Rad S, Tajeran M, Jebelli A, Shahriyari M, Bahrami M, Fallah A, Yaghoobi V, Mirahmadi M, Abbaszadegan M, Bahrami A. Suppression of dsRNA response genes and innate immunity following Oct4, Stella, and Nanos2 overexpression in mouse embryonic fibroblasts. Cytokine 2018, 106: 1-11. PMID: 29501710, DOI: 10.1016/j.cyto.2018.02.021.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCellular ReprogrammingChromosomal Proteins, Non-HistoneDNA Transposable ElementsDown-RegulationEmbryo, MammalianEndogenous RetrovirusesFibroblastsGene Regulatory NetworksHEK293 CellsHumansImmunity, InnateMice, Inbred BALB CModels, BiologicalOctamer Transcription Factor-3Promoter Regions, GeneticRepressor ProteinsRNA-Binding ProteinsRNA, Double-StrandedRNA, Long NoncodingConceptsEmbryonic stem cellsResponse genesGerm cell-specific genesDeep transcriptome analysisGerm cell developmentCell-specific genesStem cellsMouse embryonic fibroblastsTransposon suppressionDsRNA-2Interferon response genesTranscriptome analysisSelf-renewal capacityEndogenous retrotransposonsEmbryonic fibroblastsCell developmentNanos2Antiviral genesGenesInnate immune systemGene cassettesInnate immunityImmune responseCritical pathwaysFirst report
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