Suppression of dsRNA response genes and innate immunity following Oct4, Stella, and Nanos2 overexpression in mouse embryonic fibroblasts
Farshchian M, Matin M, Armant O, Geerts D, Dastpak M, Nakhaei-Rad S, Tajeran M, Jebelli A, Shahriyari M, Bahrami M, Fallah A, Yaghoobi V, Mirahmadi M, Abbaszadegan M, Bahrami A. Suppression of dsRNA response genes and innate immunity following Oct4, Stella, and Nanos2 overexpression in mouse embryonic fibroblasts. Cytokine 2018, 106: 1-11. PMID: 29501710, DOI: 10.1016/j.cyto.2018.02.021.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCellular ReprogrammingChromosomal Proteins, Non-HistoneDNA Transposable ElementsDown-RegulationEmbryo, MammalianEndogenous RetrovirusesFibroblastsGene Regulatory NetworksHEK293 CellsHumansImmunity, InnateMice, Inbred BALB CModels, BiologicalOctamer Transcription Factor-3Promoter Regions, GeneticRepressor ProteinsRNA-Binding ProteinsRNA, Double-StrandedRNA, Long NoncodingConceptsEmbryonic stem cellsResponse genesGerm cell-specific genesDeep transcriptome analysisGerm cell developmentCell-specific genesStem cellsMouse embryonic fibroblastsTransposon suppressionDsRNA-2Interferon response genesTranscriptome analysisSelf-renewal capacityEndogenous retrotransposonsEmbryonic fibroblastsCell developmentNanos2Antiviral genesGenesInnate immune systemGene cassettesInnate immunityImmune responseCritical pathwaysFirst report
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