Quantitative evaluation of incomplete preweaning lethality in mice by using the CRISPR/Cas9 system
Nakamura T, Nakajima K, Ohnishi T, Yoshikawa T, Nakanishi M, Takumi T, Tsuboi T, Kato T. Quantitative evaluation of incomplete preweaning lethality in mice by using the CRISPR/Cas9 system. Scientific Reports 2018, 8: 16025. PMID: 30375401, PMCID: PMC6207718, DOI: 10.1038/s41598-018-34270-5.Peer-Reviewed Original ResearchConceptsInternational Mouse Phenotyping ConsortiumLoss-of-functionGenome-edited micePreweaning lethalityDisease-related genesFrameshift alleleHomozygous KO miceIMPC dataMolecular biology techniquesGenome editingMouse mutantsIncomplete penetranceCRISPR/Cas9 systemGenesAssociated with lethalityEhd1 geneMouse phenotypeHomozygous knockout miceMice mutantsCRISPR/Cas9Cell linesMutantsBiology techniquesAllelesKO mice
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